Association between polymorphisms in candidate genes and morbid obesity

被引：0

作者：

D Evans

AM Wolf

U Nellessen

S Ahle

B Kortner

HW Kuhlmann

U Beisiegel

机构：

[1] Medizinische Klinik,

[2] Universitätskrankenhaus Eppendorf,undefined

[3] Klinik für Allgemeinchirurgie,undefined

[4] Evangelisches und Johanniter Klinikum,undefined

来源：

International Journal of Obesity | 2001年 / 25卷

关键词：

morbid obesity; polymorphisms;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Polymorphisms in a number of candidate genes have been reported to be associated with obesity. We have determined the incidence of the following polymorphisms in the following candidate genes in a group of 388 morbid obese patients (mean body mass index (BMI) 52±8.01) who underwent gastric banding surgery: lipoprotein lipase (LpL) t-93 g and N291S; peroxisome proliferator receptor γ (PPARγ), P12A, P115Q and c1431t; peroxisome proliferator receptor α (PPARα) L162V; β-adrenergic receptor 2 (β-AR 2), Q27E; β-adrenergic receptor 3 (β-AR 3) W64R; uncoupling protein 1 (ucp-1), a-3826g, ucp-2, 45 bp insertion. Only for the ucp2 polymorphism did we find a statistically significant association with obesity. The β-AR 3 W64R and ucp-1 a-3826g polymorphisms influenced the rate of the development of obesity and may act synergistically.

引用

页码：S19 / S21

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