Marginal zone B cells control the response of follicular helper T cells to a high-cholesterol diet

被引：0
作者：
Meritxell Nus
Andrew P Sage
Yuning Lu
Leanne Masters
Brian Y H Lam
Stephen Newland
Sandra Weller
Dimitrios Tsiantoulas
Juliette Raffort
Damiënne Marcus
Alison Finigan
Lauren Kitt
Nichola Figg
Reinhold Schirmbeck
Manfred Kneilling
Giles S H Yeo
Christoph J Binder
José Luis de la Pompa
Ziad Mallat
机构：
[1] University of Cambridge,Division of Cardiovascular Medicine
[2] Metabolic Research Laboratories,Department of Laboratory Medicine
[3] University of Cambridge and MRC Metabolic Diseases Unit,Department of Internal Medicine I
[4] Wellcome Trust–MRC Institute of Metabolic Science,Department of Preclinical Imaging and Radiopharmacy
[5] Institut Necker–Enfants Malades,Department of Dermatology
[6] INSERM U1151,undefined
[7] CNRS UMR 8253,undefined
[8] Sorbonne,undefined
[9] Paris Cité,undefined
[10] Université Paris Descartes,undefined
[11] Medical University of Vienna,undefined
[12] Center for Molecular Medicine (CeMM) of the Austrian Academy of Sciences,undefined
[13] Ulm University Hospital,undefined
[14] Werner Siemens Imaging Center,undefined
[15] Eberhard Karls University,undefined
[16] Eberhard Karls University,undefined
[17] Intercellular Signalling in Cardiovascular Development & Disease Laboratory,undefined
[18] Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC),undefined
[19] Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares,undefined
[20] INSERM,undefined
[21] Unit 970,undefined
[22] Paris Cardiovascular Research Center,undefined
来源：
Nature Medicine | 2017年 / 23卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Splenic marginal zone B cells suppress atherosclerosis in mice by dampening the proatherogenic T follicular helper response via a PDL1-dependent interaction with T follicular helper cells.
引用
收藏
页码：601 / 610
页数：9
相关论文
共 99 条
  • [1] Libby P(2013)Immune effector mechanisms implicated in atherosclerosis: from mice to humans Immunity 38 1092-1104
  • [2] Lichtman AH(2014)Adaptive (T and B cells) immunity and control by dendritic cells in atherosclerosis Circ. Res. 114 1640-1660
  • [3] Hansson GK(2014)Multiple potential roles for B cells in atherosclerosis Ann. Med. 46 297-303
  • [4] Ait-Oufella H(2015)Targeting B cells in atherosclerosis: closing the gap from bench to bedside Arterioscler. Thromb. Vasc. Biol. 35 296-302
  • [5] Sage AP(2010)B cell depletion reduces the development of atherosclerosis in mice J. Exp. Med. 207 1579-1587
  • [6] Mallat Z(2010)Conventional B2 B cell depletion ameliorates whereas its adoptive transfer aggravates atherosclerosis J. Immunol. 185 4410-4419
  • [7] Tedgui A(2012)Protective role of natural IgM-producing B1a cells in atherosclerosis Trends Cardiovasc. Med. 22 48-53
  • [8] Sage AP(2012)BAFF receptor deficiency reduces the development of atherosclerosis in mice—brief report Arterioscler. Thromb. Vasc. Biol. 32 1573-1576
  • [9] Mallat Z(2014)B10 cell regulation of health and disease Immunol. Rev. 259 259-272
  • [10] Tsiantoulas D(2015)Regulatory B cells: origin, phenotype, and function Immunity 42 607-612
12345678910