Histological complete response to a combined docetaxel/cisplatin/fluorouracil neoadjuvant chemotherapy for T4 stage gastric adenocarcinoma

被引：0
作者：
Ming gao Guo
Qi Zheng
Jian zhong Di
Zhe Yang
机构：
[1] Shanghai Jiaotong University,Department of Surgery, the Six People’s Hospital of Shanghai
来源：
World Journal of Surgical Oncology | / 12卷
关键词：
Gastric cancer; neoadjuvant chemotherapy; docetaxel; cisplatin; fluorouracil;
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摘要：
Local advanced gastric carcinoma has a very poor prognosis. When a T4 gastric carcinoma has invaded the surrounding tissues and organs, curative resection is unlikely. We present here a case of a 63-year-old woman with a T4 unresectable gastric adenocarcinoma. She underwent two 3-week cycles of docetaxel/cisplatin/fluorouracil chemotherapy, followed by radical gastric resection. Each cycle consisted of 75 mg/m2 docetaxel and 75 mg/m2 cisplatin on day 1, and 200 mg/m2 leucovorin and 500 mg/m2 fluorouracil on days 1 through 5. The patient exhibited a complete histologic response. Our results indicate that docetaxel/cisplatin/fluorouracil neoadjuvant chemotherapy is a promising method of treatment for advanced gastric cancer.
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