Diagnostic criteria for slowly progressive insulin-dependent (type 1) diabetes mellitus (SPIDDM) (2012): report by the Committee on Slowly Progressive Insulin-Dependent (Type 1) Diabetes Mellitus of the Japan Diabetes Society

被引：52

作者：

Tanaka S. ^{[1
]}

Ohmori M. ^{[1
]}

Awata T. ^{[2
]}

Shimada A. ^{[3
]}

Murao S. ^{[4
]}

Maruyama T. ^{[5
]}

Kamoi K. ^{[6
]}

Kawasaki E. ^{[7
]}

Nakanishi K. ^{[8
]}

Nagata M. ^{[9
]}

Fujii S. ^{[10
]}

Ikegami H. ^{[11
]}

Imagawa A. ^{[12
]}

Uchigata Y. ^{[13
]}

Okubo M. ^{[14
]}

Osawa H. ^{[15
]}

Kajio H. ^{[16
]}

Kawaguchi A. ^{[1
]}

Kawabata Y. ^{[11
]}

Satoh J. ^{[17
]}

Shimizu I. ^{[18
]}

Takahashi K. ^{[17
]}

Makino H. ^{[19
]}

Iwahashi H. ^{[12
]}

Miura J. ^{[13
]}

Yasuda K. ^{[20
]}

Hanafusa T. ^{[21
]}

Kobayashi T. ^{[1
,22
]}

机构：

[1] Third Department of Internal Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 1110 Shimokato, Chuo, 409-3898, Yamanashi

[2] Department of Endocrinology and Diabetes, Saitama Medical University, Saitama

[3] Department of Internal Medicine, Saiseikai Central Hospital, Tokyo

[4] Department of Diabetes and Endocrinology, Takamatsu Hospital, Kagawa

[5] Department of Internal Medicine, Saitama Social Insurance Hospital, Saitama

[6] The Diabetes and Endocrine and Metabolism Disease Center, Ojiya General Hospital, Niigata

[7] Department of Metabolism/Diabetes and Clinical Nutrition, Nagasaki University Hospital, Nagasaki

[8] Department of Diabetes, Minami-isshiki Central Clinic, Shizuoka

[9] Department of Internal Medicine, Kakogawa West City Hospital, Hyogo

[10] Diabetology and Endocrinology, Ishikawa Prefectural Central Hospital, Ishikawa

[11] Department of Endocrinology, Metabolism and Diabetes, Kinki University School of Medicine, Osaka

[12] Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka

[13] Diabetes Center, Tokyo Women’s Medical University School of Medicine, Tokyo

[14] Department of Endocrinology and Metabolism, Toranomon Hospital, Tokyo

[15] Department of Molecular and Genetic Medicine, Ehime University Graduate School of Medicine, Ehime

[16] Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, National Center for Global Health and Medicine Hospital, Tokyo

[17] Department of Diabetes and Metabolism, Iwate Medical University, Iwate

[18] Department of Diabetic Medicine, The Sakakibara Heart Institute of Okayama, Okayama

[19] Diabetes Center, Shiraishi Hospital, Ehime

[20] Department of Metabolic Disorder, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Tokyo

[21] Department of Internal Medicine (I), Osaka Medical College, Osaka

[22] Okinaka Memorial Institute for Medical Research, Tokyo

来源：

Diabetology International | 2015年 / 6卷 / 1期

基金：

日本学术振兴会;

关键词：

Diagnostic criteria; Glutamic acid decarboxylase antibodies; Insulin autoantibodies; Insulinoma-associated antigen-2 antibodies; Islet cell antibodies; Slowly progressive insulin-dependent (type 1) diabetes mellitus;

D O I：

10.1007/s13340-014-0199-2

中图分类号：

学科分类号：

摘要：

Diagnostic criteria for slowly progressive insulin-dependent (Type 1) diabetes mellitus (SPIDDM) have been proposed by the Committee on Slowly Progressive Insulin-dependent (type 1) Diabetes Mellitus of the Japan Diabetes Society. Two criteria must be met for definitive diagnosis: the presence of glutamic acid decarboxylase antibodies (GADAb) and/or islet cell antibodies (ICA) at some time during the clinical course of the diabetes, and the absence of ketosis or ketoacidosis at the onset (or diagnosis) of diabetes mellitus and no need for insulin treatment to correct hyperglycemia immediately after diagnosis. It is still unclear whether insulinoma-associated antigen-2 autoantibodies (IA-2Ab), insulin autoantibodies (IAA), or zinc transporter 8 autoantibodies (ZnT8Ab) are essential markers for diagnosis for SPIDDM. Hence, the presence of IA-2Ab, IAA, and ZnT8Ab were excluded from these diagnostic criteria for SPIDDM. Furthermore, ketosis or ketoacidosis can be observed in cases in which SPIDDM is complicated by soft-drink ketosis. Supplementary information for diagnosis include: most SPIDDM patients will need insulin treatment more than 3 months after onset (or diagnosis) of diabetes mellitus and frequently progress to an insulin-dependent state; sometimes, for clinical reasons, early insulin treatment is started when GADAb or ICA are positive both for child and adult-onset cases; GADAb and/or ICA often become negative during the course of the disease; and a small proportion of patients might maintain endogenous beta-cell function more than 10 years after the onset (or diagnosis) of diabetes mellitus, irrespective of the titer of GADAb and ICA. © 2015, The Japan Diabetes Society.

引用

页码：1 / 7

页数：7

共 22 条

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