Synthesis, Structure Elucidation and Antimicrobial Properties of New Bis-1,3,4-Oxadiazole Derivatives

被引：0
作者：
Taoufik Rohand
Youssef Ramli
Mukulesh Baruah
Jan Budka
Archana M. Das
机构：
[1] Université Cadi Ayyad,Laboratoire de Chimie Analytique et Moléculaire, Département de Chimie
[2] Faculté Polydisciplinaire Safi,Laboratoire de ChimieThérapeutique
[3] Université Mohamed V,Department of Chemistry
[4] Faculté de Médecineet de Pharmacie de Rabat,Department of Organic Chemistry
[5] The Assam Kaziranga University,undefined
[6] University of Chemistry and Technology,undefined
[7] Natural Products Chemistry Division,undefined
[8] CSIR,undefined
[9] North East Institute of Science and Technology,undefined
来源：
Pharmaceutical Chemistry Journal | 2019年 / 53卷
关键词：
1,3,4-bis-oxadiazoles; quaternary ammonium salts; antibacterial activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Four new 1,3,4-bis-oxadiazole derivatives were synthesized, two of them bearing quaternary ammonium salts. The newly synthesized bis-1,3,4-oxadiazoles were investigated for their antibacterial activity against various Gram-positive and Gram-negative strains of bacteria. The target products were prepared from 2-(dimethylamino)ethyl methacrylate (DMAEMA) or 2-(diethylamino)ethyl methacrylate (DEAEMA) via reactions with hexanedioic acid. The structures of all synthesized compounds were confirmed by IR, 1H-NMR, and 13C-NMR spectroscopy. The results of biological activity testing showed that two compounds exhibited the best antibacterial activity against Citrobacterfreundii (ATCC 8090) and Methicillin-resistant Staphylococcus aureus (ATCC 43300) strains.
引用
收藏
页码：150 / 154
页数：4
相关论文
共 88 条
  • [1] Pace A(2009)undefined Org. Biomol. Chem. 7 4337-4348
  • [2] Pierro P(2005)undefined Arch. Pharm. 338 78-86
  • [3] Bethge K(2002)undefined Chem. Res. Toxicol. 15 269-299
  • [4] Pertz HH(2009)undefined Pharm. Chem. J. 43 148-153
  • [5] Rehse K(2009)undefined Bioorg. Med. Chem. Lett. 19 4773-4776
  • [6] Dalvie DK(2012)undefined J. Med. Chem. 55 1817-1830
  • [7] Kalgutkar AS(2000)undefined Il Farmaco 55 719-724
  • [8] Khojasteh-Bakht SC(2007)undefined Carbohydr. Res. 342 2440-2449
  • [9] Ryzhova EA(2015)undefined Current Org. Synth. 12 1-6
  • [10] Koryakova AG(2006)undefined Xenobiotica 36 399-418
123456789