Angiogenic molecules and mechanisms in breast cancer.

被引：2
作者：
Wu I. [1 ]
Moses M.A. [1 ]
机构：
[1] Laboratory for Surgical Research, The Children's Hospital, and Department of Surgery, Harvard Medical School, 300 Longwood Avenue, Boston
来源：
Current Oncology Reports | 2000年 / 2卷 / 6期
基金：
美国国家卫生研究院;
关键词：
Breast Cancer; Vascular Endothelial Growth Factor; Factor Vascular Endothelial Cell Growth; Human Breast Carcinoma Cell; Malignant Epithelial Cell;
D O I：
10.1007/s11912-000-0111-z
中图分类号：
学科分类号：
摘要：
One of the most promising and exciting anti-cancer strategies is one that is based on the inhibition of angiogenesis. Unlike conventional therapeutic approaches, anti-angiogenic therapy holds the unique promise of treating the disease in the absence of cytotoxicity or drug resistance. The link between angiogenesis and the progression of human breast cancer has been known for over 25 years, yet it is only in recent years, as endogenous stimulators and inhibitors of angiogenesis have been discovered and studied, that the promise of this therapeutic approach for breast cancer has come to be appreciated. This article presents a concise review of recent studies focused on the molecules and mechanisms that are related to the role of angiogenesis in breast cancer.
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收藏
页码：566 / 571
页数：5
相关论文
共 133 条
[31]  
Houck KA(1999)Antiangiogenic activity of the cleaved conformation of the serpin antithrombin Science 285 1926-1928
[32]  
Ferrara N(1994)Transfection of thrombospondin-1 complementary DNA into a human breast carcinoma cell line reduces primary tumor growth, metastatic potential, and angiogenesis Cancer Res 54 6504-6511
[33]  
Winer J(1994)Control of angiogenesis in fibroblast by p53 regulation of thrombospondin-1 Science 265 1582-1585
[34]  
de Jong JS(1999)Liposomes complexed to plasmids encoding angiostatin and endostatin inhibit breast cancer in nude mice Cancer Res 59 3308-3312
[35]  
van Diest PJ(1997)Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras-transformed cells through a hypoxia inducible factor-1 transcriptional element Blood 90 3322-33313
[36]  
van der Valk P(1999)Inverse regulation of vascular endothelial growth factor and VHL tumor suppressor gene in sporadic renal cell carcinoma is correlated with vascular growth: an in vivo study on 29 tumors J Mol Med 77 505-510
[37]  
Baak JP(1998)MDM-2 oncoprotein overexpression, p53 gene mutation, and VEGF up-regulation in angiosarcomas Am J Pathol 153 1425-1433
[38]  
Brown LF(1994)Control of angiogenesis in fibroblast by p53 regulation of thrombospondin-1 Science 265 1582-1585
[39]  
Guidi Aj(1999)Down-regulation of endothelial cell growth inhibitors by enhanced MYCN oncogene expression in human neuroblastoma cells Eur J Biochem 263 757-764
[40]  
Schnitt SJ(1996)Involvement of the transcription factor NF-kappaB in tubular morphogenesis of human microvascular endothelial cells by oxidative stress Mol Cell Biol 16 4231-4239
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