Angiogenic molecules and mechanisms in breast cancer.

被引：2
作者：
Wu I. [1 ]
Moses M.A. [1 ]
机构：
[1] Laboratory for Surgical Research, The Children's Hospital, and Department of Surgery, Harvard Medical School, 300 Longwood Avenue, Boston
来源：
Current Oncology Reports | 2000年 / 2卷 / 6期
基金：
美国国家卫生研究院;
关键词：
Breast Cancer; Vascular Endothelial Growth Factor; Factor Vascular Endothelial Cell Growth; Human Breast Carcinoma Cell; Malignant Epithelial Cell;
D O I：
10.1007/s11912-000-0111-z
中图分类号：
学科分类号：
摘要：
One of the most promising and exciting anti-cancer strategies is one that is based on the inhibition of angiogenesis. Unlike conventional therapeutic approaches, anti-angiogenic therapy holds the unique promise of treating the disease in the absence of cytotoxicity or drug resistance. The link between angiogenesis and the progression of human breast cancer has been known for over 25 years, yet it is only in recent years, as endogenous stimulators and inhibitors of angiogenesis have been discovered and studied, that the promise of this therapeutic approach for breast cancer has come to be appreciated. This article presents a concise review of recent studies focused on the molecules and mechanisms that are related to the role of angiogenesis in breast cancer.
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收藏
页码：566 / 571
页数：5
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