Membrane curvature regulates ligand-specific membrane sorting of GPCRs in living cells

被引：0
|
作者：
Kadla R Rosholm
Natascha Leijnse
Anna Mantsiou
Vadym Tkach
Søren L Pedersen
Volker F Wirth
Lene B Oddershede
Knud J Jensen
Karen L Martinez
Nikos S Hatzakis
Poul Martin Bendix
Andrew Callan-Jones
Dimitrios Stamou
机构：
[1] Bionanotechnology and Nanomedicine Laboratory,Department of Chemistry
[2] Nano-Science Center,Department of Chemistry
[3] University of Copenhagen,Department of Chemistry and Nano
[4] Lundbeck Foundation Center Biomembranes in Nanomedicine,Science Center
[5] University of Copenhagen,undefined
[6] Niels Bohr Institute,undefined
[7] University of Copenhagen,undefined
[8] University of Copenhagen,undefined
[9] Laboratoire Matière et Systèmes Complexes,undefined
[10] Université Paris-Diderot,undefined
[11] The Victor Chang Cardiac Research Institute,undefined
[12] Gubra Aps,undefined
[13] University of Copenhagen,undefined
来源：
Nature Chemical Biology | 2017年 / 13卷
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学科分类号：
摘要：
Membrane curvature induces sorting of GPCRs within live-cell-membrane protrusions, and the curvature-dependent sorting is affected by agonist binding. Thermodynamic modeling suggests that this is due to an energetic drive to match receptor shape and elasticity to membrane curvature.[graphic not available: see fulltext]
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页码：724 / 729
页数：5
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