Oral anticoagulants in older adults with atrial fibrillation

被引:0
作者
Gwen M. Bernacki
Richard C. Becker
机构
[1] Duke Clinical Research Institute,Division of Cardiology, Duke University Medical Center
[2] Duke Clinical Research Institute,Divisions of Cardiology and Hematology, Duke University Medical Center
来源
Journal of Thrombosis and Thrombolysis | 2013年 / 36卷
关键词
Atrial fibrillation; Novel oral anticoagulant; Older adult;
D O I
暂无
中图分类号
学科分类号
摘要
Atrial fibrillation (AF) is the most common arrhythmia in adults and contributes directly to adverse clinical events, ranging from ischemic stroke to heart failure and cardiovascular death. Because the incidence of AF and its attendant complications increase with age, there is a strong and growing need to develop safe, effective and widely available therapies. The following review summarizes the use of oral anticoagulants in older adults with AF, focusing on practical topics such as drug metabolism, drug–drug interactions, co-morbidities and cost considerations in a complex payer environment.
引用
收藏
页码:403 / 415
页数:12
相关论文
共 473 条
[1]  
Brubaker TH(1976)The stereotype of “old.” A review and alternative approach J Gerontol 31 441-447
[2]  
Powers EA(1999)Content and function of the self-definition in old and very old age J Gerontol B 54 P55-P67
[3]  
Freund AM(2012)Drug policy for an aging population—the European Medicines Agency’s geriatric medicines strategy N Engl J Med 367 1972-1974
[4]  
Smith J(2006)Prevalence, incidence and lifetime risk of atrial fibrillation: the Rotterdam Study Eur Heart J 27 949-953
[5]  
Cerreta F(1987)Atrial fibrillation: a major contributor to stroke in the elderly. The Framingham Study Arch Intern Med 147 1561-1564
[6]  
Eichler HG(2011)Atrial fibrillation, anticoagulation, fall risk, and outcomes in elderly patients Am Heart J 161 241-246
[7]  
Rasi G(2007)Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation Ann Intern Med 146 857-867
[8]  
Heeringa J(1999)Warfarin use among ambulatory patients with nonvalvular atrial fibrillation: the anticoagulation and risk factors in atrial fibrillation (ATRIA) study Ann Intern Med 131 927-934
[9]  
van der Kuip DA(2004)Aging biology and geriatric clinical pharmacology Pharmacol Rev 56 163-184
[10]  
Hofman A(2009)Pharmacokinetics and drug metabolism in the elderly Drug Metab Rev 41 67-76