Design and biological activity of synthetic oligopeptides with Pro-His-Ser-Arg-Asn (PHSRN) and Arg-Gly-Asp (RGD) motifs for human osteoblast-like cell (MG-63) adhesion

被引：0
作者：
Tae-Il Kim
Jun-Hyeog Jang
Yong-Moo Lee
In-Cheol Ryu
Chong-Pyoung Chung
Soo-Boo Han
Sang-Mook Choi
Young Ku
机构：
[1] Seoul National University,Department of Periodontology, College of Dentistry
[2] Seoul National University,undefined
来源：
Biotechnology Letters | 2002年 / 24卷
关键词：
fibronectin; mitogen-activated protein kinase; oligopeptides; osteoblast-like cell;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A synthetic oligopeptide, composed of Arg-Gly-Asp (RGD) and its synergistic Pro-His-Ser-Arg-Asn (PHSRN) motifs and a six glycines (G6) linker, promoted human osteoblast-like cell (MG-63) adhesion, spreading and mitogen-activated protein kinase (MAPK) activity in a similar manner to a positive fibronectin control. This synthetic oligopeptide may therefore be a useful osteo-inductive material.
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页码：2029 / 2033
页数：4
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