Chromosomal localization of 13 candidate genes for human obesity in the pig genome

被引：0
作者：
Joanna Nowacka-Woszuk
Izabela Szczerbal
Honorata Fijak-Nowak
Marek Switonski
机构：
[1] Poznan University of Life Sciences,Department of Genetics and Animal Breeding
来源：
Journal of Applied Genetics | 2008年 / 49卷
关键词：
candidate gene; fatness; obesity; pig;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Thirteen candidate genes for human obesity were selected for cytogenetic mapping by FISH in the pig genome. Among them, 6 genes were assigned to chromosomes for the first time (NR3C1, GNB3, ADRB1, ADRB2, ADRB3 andUCP1). Location of the other 7 genes (INSIG2, LIPIN1, PLIN, NAMPT, ADIPOQ, UCP2 andUCP3), earlier mapped by somatic cell hybridization or with the use of a radiation hybrid panel, was verified (INSIG2) or more precisely described. The genes were assigned to the following chromosomes:INSIG2 to SSC15q12,LIPIN1 to SSC3q26,NR3C1 to SSC2q29,PLIN to SSC7q15,GNB3 to SSC5q21,NAMPT to SSC9q23,ADIPOQ to SSC13q41,ADRB1 to SSC14q28,ADRB2 to SSC2q29,ADRB3 to SSC15q13-14,UCP1 to SSC8q21-22, and bothUCP2 andUCP3 to SSC9p24. Most of the genes were located within known QTL for pig fatness traits.
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页码：373 / 377
页数：4
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