The application of gene therapy in autoimmune diseases

被引：0
作者：
C M Seroogy
C G Fathman
机构：
[1] Stanford University School of Medicine,Department of Medicine, Division of Immunology and Rheumatology
来源：
Gene Therapy | 2000年 / 7卷
关键词：
gene therapy; autoimmune disease; CD4; T cell;
D O I：
暂无
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学科分类号：
摘要：
The application of gene therapy in autoimmune disease represents a novel use of this technology. The goal of gene therapy in the treatment of autoimmune disease is to restore ‘immune homeostasis’ by countering the pro-inflammatory effects of the CD4+ T cells in the lesions of autoimmunity. This can be accomplished by adoptive therapy with transduced T cells which can specifically home to the site of inflammation and secrete ‘regulatory’ protein(s) to ameliorate the inflammation or by direct targeting of the retroviral vector to activated T cells in the sites of inflammation. Transduction of autoantigen recognizing CD4+ T cells, to secrete anti-inflammatory products, may become the ‘magic bullet’ to combat the ravages of autoimmune inflammation and tissue destruction.
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页码：9 / 13
页数：4
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