Nangibotide in patients with septic shock: a Phase 2a randomized controlled clinical trial

被引:0
作者
Bruno François
Xavier Wittebole
Ricard Ferrer
Jean-Paul Mira
Thierry Dugernier
Sébastien Gibot
Marc Derive
Aurélie Olivier
Valérie Cuvier
Stephan Witte
Peter Pickkers
François Vandenhende
Jean-Jacques Garaud
Miguel Sánchez
Margarita Salcedo-Magguilli
Pierre-François Laterre
机构
[1] CHU Limoges,Medical
[2] Université Catholique de Louvain,Surgical ICU Department and Inserm CIC1435 & UMR1092, CRICS
[3] Vall d’Hebron University Hospital,TRIGGERSEP Network
[4] Cochin Hotel-Dieu,Department of Critical Care Medicine, St Luc University Hospital
[5] AP-HP,ICU Department
[6] Clinique St. Pierre,Medical ICU
[7] CHU Nancy,ICU Department
[8] Lorraine University,Medical ICU Department, Hospital Central
[9] Inotrem SA,Inserm U1116, Nancy Medical Faculty
[10] Helion Pharma,ICU Department
[11] Radboudumc Hospital,ICU Department
[12] ClinBay SPRL,undefined
[13] Hospital Clínico San Carlos,undefined
来源
Intensive Care Medicine | 2020年 / 46卷
关键词
Nangibotide; LR12; TREM-1; Septic shock;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:1425 / 1437
页数:12
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[1]  
Rudd KE(2020)Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study The Lancet 395 200-211
[2]  
Johnson SC(2017)Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016 Intensive Care Med 43 304-377
[3]  
Agesa KM(2011)A genomic storm in critically injured humans J Exp Med 208 2581-2590
[4]  
Shackelford KA(2001)TREM-1 amplifies inflammation and is a crucial mediator of septic shock Nature 410 1103-1107
[5]  
Tsoi D(2003)TREM-1 (triggering receptor expressed on myeloid cells): a new player in acute inflammatory responses J Infect Dis 187 S397-S401
[6]  
Kievlan DR(2000)Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes J Immunol 164 4991-4995
[7]  
Colombara DV(2010)Triggering receptor expressed on myeloid cells-1 as a new therapeutic target during inflammatory diseases Self Nonself 1 225-230
[8]  
Ikuta KS(2017)Triggering receptor expressed on myeloid cells-1: a new player in platelet aggregation Thromb Haemost 117 1772-1781
[9]  
Kissoon N(2018)Targeted endothelial gene deletion of triggering receptor expressed on myeloid cells-1 protects mice during septic shock Cardiovasc Res 114 907-918
[10]  
Finfer S(2005)Surface and soluble triggering receptor expressed on myeloid cells-1: expression patterns in murine sepsis Crit Care Med 33 1787-1793