Increased expression of cyclooxygenase-2 and nitric oxide synthase-2 in human prostate cancer

被引：0

作者：

Pekka Uotila

Eeva Valve

Paula Martikainen

Marja Nevalainen

Martti Nurmi

Pirkko Härkönen

机构：

[1] Departments of Physiology and Clinical Physiology,

[2] University of Turku,undefined

[3] Kiinamyllynkatu 10,undefined

[4] 20520 Turku,undefined

[5] Finland e-mail: Pekka.Uotila@utu.fi Tel.: +358-2-3337577; Fax: +358-2-2502610,undefined

[6] Department of Anatomy,undefined

[7] University of Turku,undefined

[8] 20520 Turku,undefined

[9] Finland,undefined

[10] Department of Pathology,undefined

[11] Tampere University Hospital,undefined

[12] 33521 Tampere,undefined

[13] Finland,undefined

[14] Department of Surgery,undefined

[15] University of Turku,undefined

[16] 20521 Turku,undefined

[17] Finland,undefined

来源：

Urological Research | 2001年 / 29卷

关键词：

Key words Prostate cancer; Prostatic intraepithelial neoplasia; Cyclooxygenase-1; Cyclooxygenase-2; Nitric oxide synthase-2;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase-2 (NOS-2) each have an important role in angiogenesis. The expression of these genes was investigated in human prostate cancer by immunohistochemistry, the expression of COX-1 and COX-2 being confirmed by mRNA analysis. Prostate cancer specimens from 12 patients were compared to control prostates from 13 patients operated on for bladder carcinoma. The intensity of COX-2 and NOS-2 immunostaining was significantly stronger in prostate cancer cells than in the non-malignant glandular epithelium of the control prostates. COX-2 and NOS-2 were clearly also expressed in the lesions of prostatic intraepithelial neoplasia (PIN) in control prostates. COX-2 was detected in the muscle fibres of the hyperplastic stroma of some control prostates. No significant difference was detected in COX-1 expression between control and cancer prostates. These results indicate that the expression of COX-2 and NOS-2 is elevated in prostatic adenocarcinoma and in PIN.

引用

页码：25 / 28

页数：3