Role of Dopamine Receptors in ADHD: A Systematic Meta-analysis

被引：0
作者：
Jing Wu
Haifan Xiao
Hongjuan Sun
Li Zou
Ling-Qiang Zhu
机构：
[1] Huazhong University of Science and Technology,Department of Epidemiology and Biostatistics and Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College
[2] Huazhong University of Science and Technology,Department of Pathophysiology and Key Lab of Neurological Disease of Education Ministry, Tongji Medical College
来源：
Molecular Neurobiology | 2012年 / 45卷
关键词：
ADHD; Dopamine receptor; Meta-analysis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The dopaminergic system plays a pivotal role in the central nervous system via its five diverse receptors (D1–D5). Dysfunction of dopaminergic system is implicated in many neuropsychological diseases, including attention deficit hyperactivity disorder (ADHD), a common mental disorder that prevalent in childhood. Understanding the relationship of five different dopamine (DA) receptors with ADHD will help us to elucidate different roles of these receptors and to develop therapeutic approaches of ADHD. This review summarized the ongoing research of DA receptor genes in ADHD pathogenesis and gathered the past published data with meta-analysis and revealed the high risk of DRD5, DRD2, and DRD4 polymorphisms in ADHD.
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页码：605 / 620
页数：15
相关论文
共 1351 条
[91]  
Banaschewski T(1992) gene is associated with attention deficit hyperactivity disorder Genomics 14 1010-513
[92]  
Becker K(2011)Association and linkage of DRD4 and DRD5 with attention deficit hyperactivity disorder (ADHD) in a sample of Turkish children Pharmacol Rev 63 182-19900
[93]  
Scherag S(2003)Dopamine system genes and attention deficit hyperactivity disorder: a meta-analysis Biochem Biophys Res Commun 306 544-8486
[94]  
Franke B(2002)Transmission disequilibrium testing of dopamine-related candidate gene polymorphisms in ADHD: confirmation of association of ADHD with DRD4 and DRD5 Mol Pharmacol 62 507-3188
[95]  
Coghill D(1999)A dinucleotide repeat polymorphism at the gene for monoamine oxidase A and measures of aggressiveness J Biol Chem 274 19894-7628
[96]  
Gizer IR(2002)Structure and linkage of the D2 dopamine receptor and neural cell adhesion molecule genes on human chromosome 11q23 J Neurosci 22 8476-213
[97]  
Ficks C(1986)The physiology, signaling, and pharmacology of dopamine receptors J Neurosci 6 3177-475
[98]  
Waldman ID(1989)Oligomerization of adenosine A2A and dopamine D2 receptors in living cells Proc Natl Acad Sci USA 86 7625-734
[99]  
Sibley DR(1989)D2 and D3 dopamine receptor cell surface localization mediated by interaction with protein 4.1 N FEBS Lett 253 207-203
[100]  
Monsma FJ(2005)Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein J Comp Neurol 488 464-165
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