Association of Bladder Cancer Risk with an NAD(P)H:Quinone Oxidoreductase Polymorphism in an Ethnic Kashmiri Population

被引：0
作者：
Arshad A. Pandith
Nighat P. Khan
Zafar A. Shah
Amin M. Shah
Saleem M. Wani
Mushtaq A. Siddiqi
机构：
[1] Sher-I-Kashmir Institute of Medical Sciences,Department of Immunology and Molecular Medicine
[2] Sher-I-Kashmir Institute of Medical Sciences,Department of Biochemistry
[3] Sher-I-Kashmir Institute of Medical Sciences,Department of Urology
来源：
Biochemical Genetics | 2011年 / 49卷
关键词：
Bladder cancer; Kashmiri; Polymorphism; Quinone oxidoreductase;
D O I：
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中图分类号：
学科分类号：
摘要：
NQO1 gene polymorphism at nucleotide 609 (Pro187Ser) results in a lowering of NQO1 detoxifying activity and is associated with susceptibility to various cancers. The NQO1 genotypes were identified by RFLP in 104 bladder cancer cases and 120 control subjects in an ethnic Kashmiri population. The frequency of the variant NQO1 alleles (CT/TT) was 23.3% for controls and 32.2% for cases (P < 0.05). Overall, the variant alleles were associated with a higher risk of bladder cancer in cases than in the control group (OR = 1.90; 95% CI 1.17–3.04; P < 0.01). In addition, the variant allele genotypes (CT/TT) were associated with a risk of bladder cancer that was more than threefold higher in smokers (OR = 3.47; 95% CI 1.84–6.3; P < 0.001). Results of this study strongly suggest that the variant allele of NQO1 (Pro187Ser) may affect individual susceptibility to bladder cancer, particularly among smokers, in this ethnic Kashmiri population.
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页码：417 / 426
页数：9
相关论文
共 244 条
[1]  
Arshad AP(2010)Activated H-ras gene mutations in transitional cell carcinoma of urinary bladder in a Kashmiri population Tumori 96 993-998
[2]  
Zafar S(2001)Regulation of p53 stability and p53-dependent apoptosis by NADH quinone oxidoreductase 1 Proc Natl Acad Sci USA 89 1188-1193
[3]  
Roohi R(2002)Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by Proc Natl Acad Sci USA 99 13125-13130
[4]  
Dil-Afroze Y(1989)Increased sensitivity of quinone resistant cells to mitomycin C Cancer Lett 45 173-176
[5]  
Adfar P(1997)Induction of DT-diaphorase in cancer chemoprevention and chemotherapy Oncol Res 9 371-382
[6]  
Nighat W(2000)Molecular genetics of cancer susceptibility Pharmacology 61 212-227
[7]  
Saleem Siddiqi(2006)NAD(P)H:quinone oxidoreductase 1 ( Cancer Epidemiol Biomarkers Prev 15 979-987
[8]  
Mushtaq G(1999)) Pro187Ser polymorphism and the risk of lung, bladder, and colorectal cancers: a meta-analysis Cancer Res 59 3045-3048
[9]  
Asher J(2003)Association of the NAD (P)H:quinone oxidoreductase 609C→T polymorphism with a decreased lung cancer risk Pharmacogenetics 13 349-355
[10]  
Lotem B(2001)CYP2E1 and Br J Cancer 85 1137-1146
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