Abnormal accumulation of extracellular vesicles in hippocampal dystrophic axons and regulation by the primary cilia in Alzheimer’s disease

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作者
Jaemyung Jang
Seungeun Yeo
Soonbong Baek
Hyun Jin Jung
Mi Suk Lee
Seung Hee Choi
Youngshik Choe
机构
[1] Korea Brain Research Institute,
来源
Acta Neuropathologica Communications | / 11卷
关键词
Dystrophic neurites; Primary cilia; Hippocampal septal connection; Extracellular vesicles; Single cell RNA sequencing; Selectively vulnerable neurons;
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  • [1] Ahmad FJ(1995)Microtubules released from the neuronal centrosome are transported into the axon J Cell Sci 108 2761-2769
  • [2] Baas PW(2010)Mechanisms of axonal spheroid formation in central nervous system Wallerian degeneration J Neuropathol Exp Neurol 69 455-472
  • [3] Beirowski B(2020)Distinct dorsal and ventral hippocampal CA3 outputs govern contextual fear discrimination Cell Rep 30 2360-2373
  • [4] Nogradi A(1982)Loss of neurons of origin of the adrenergic projection to cerebral cortex (nucleus locus ceruleus) in senile dementia Neurology 32 164-168
  • [5] Babetto E(2018)Morphological diversity and connectivity of hippocampal interneurons Cell Tissue Res 373 619-641
  • [6] Garcia-Alias G(2019)Interplay between primary cilia, ubiquitin-proteasome system and autophagy Biochimie 166 286-292
  • [7] Coleman MP(2012)Axonal transport of APP and the spatial regulation of APP cleavage and function in neuronal cells Exp Brain Res 217 353-364
  • [8] Besnard A(2010)The p75 neurotrophin receptor is localized to primary cilia in adult murine hippocampal dentate gyrus granule cells Biochem Biophys Res Commun 401 458-462
  • [9] Miller SM(2022)Bulk and single-nucleus transcriptomics highlight intra-telencephalic and somatostatin neurons in Alzheimer’s disease Front Mol Neurosci 15 903175-506
  • [10] Sahay A(2018)Spatial navigation deficits: overlooked cognitive marker for preclinical Alzheimer disease? Nat Rev Neurol 14 496-1140