The interplay of sensory feedback, arousal, and action tremor amplitude in essential tremor
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作者:
Julius Welzel
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机构:University Hospital Schleswig-Holstein,Department of Psychology
Julius Welzel
Miriam Güthe
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机构:University Hospital Schleswig-Holstein,Department of Psychology
Miriam Güthe
Julian Keil
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机构:University Hospital Schleswig-Holstein,Department of Psychology
Julian Keil
Gesine Hermann
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机构:University Hospital Schleswig-Holstein,Department of Psychology
Gesine Hermann
Robin Wolke
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机构:University Hospital Schleswig-Holstein,Department of Psychology
Robin Wolke
Walter Maetzler
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机构:University Hospital Schleswig-Holstein,Department of Psychology
Walter Maetzler
Jos S. Becktepe
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机构:University Hospital Schleswig-Holstein,Department of Psychology
Jos S. Becktepe
机构:
[1] University Hospital Schleswig-Holstein,Department of Psychology
[2] University of Kiel,undefined
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Scientific Reports
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摘要:
Essential tremor (ET) amplitude is modulated by visual feedback during target driven movements and in a grip force task. It has not been examined yet whether visual feedback exclusively modulates target force tremor amplitude or if other afferent inputs like auditory sensation has a modulatory effect on tremor amplitude as well. Also, it is unknown whether the enhanced sensory feedback causes an increase of arousal in persons with ET (p-ET). We hypothesized that (1) amplitude of tremor is modulated by variation of auditory feedback in the absence of visual feedback in a force tremor paradigm; (2) increase of tremor amplitude coincides with pupillary size as a measure of arousal. 14 p-ET and 14 matched healthy controls (HC) conducted a computer-based experiment in which they were asked to match a target force on a force sensor using their thumb and index finger. The force-induced movement was fed back to the participant visually, auditory or by a combination of both. Results showed a comparable deviation from the target force (RMSE) during the experiment during all three sensory feedback modalities. The ANOVA revealed an effect of the high vs. low feedback condition on the tremor severity (Power 4–12 Hz) for the visual- and also for the auditory feedback condition in p-ET. Pupillometry showed a significantly increased pupil diameter during the auditory involved high feedback conditions compared to the low feedback conditions in p-ET. Our findings suggest that action tremor in ET is firstly modulated not only by visual feedback but also by auditory feedback in a comparable manner. Therefore, tremor modulation seems to be modality independent. Secondly, high feedback was associated with a significant pupil dilation, possibly mirroring an increased arousal/perceived effort.
机构:
Columbia Univ, Coll Phys & Surg, Taub Inst Res Alzheimers Dis & Aging Brain, GH Sergievsky Ctr,Dept Neurol, New York, NY 10027 USA
Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY USAColumbia Univ, Coll Phys & Surg, Taub Inst Res Alzheimers Dis & Aging Brain, GH Sergievsky Ctr,Dept Neurol, New York, NY 10027 USA
Louis, Elan D.
Pellegrino, Kathryn M.
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机构:Columbia Univ, Coll Phys & Surg, Taub Inst Res Alzheimers Dis & Aging Brain, GH Sergievsky Ctr,Dept Neurol, New York, NY 10027 USA
Pellegrino, Kathryn M.
Rios, Eileen
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机构:Columbia Univ, Coll Phys & Surg, Taub Inst Res Alzheimers Dis & Aging Brain, GH Sergievsky Ctr,Dept Neurol, New York, NY 10027 USA
机构:
Univ Texas Southwestern Med Ctr, Med Sch, Dallas, TX USAUniv Texas Southwestern Med Ctr, Med Sch, Dallas, TX USA
Hernandez, Adreanna B.
Berry, Diane S.
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Univ Texas Southwestern Med Ctr, Dept Neurol, Dallas, TX USAUniv Texas Southwestern Med Ctr, Med Sch, Dallas, TX USA
Berry, Diane S.
Grill, Natalie
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Univ Texas Southwestern Med Ctr, Dept Neurol, Dallas, TX USAUniv Texas Southwestern Med Ctr, Med Sch, Dallas, TX USA
Grill, Natalie
Hall, Talia M.
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Univ Texas Southwestern Med Ctr, Dept Neurol, Dallas, TX USAUniv Texas Southwestern Med Ctr, Med Sch, Dallas, TX USA
Hall, Talia M.
Burkes, Allison
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Univ Texas Southwestern Med Ctr, Dept Neurol, Dallas, TX USAUniv Texas Southwestern Med Ctr, Med Sch, Dallas, TX USA
Burkes, Allison
Ghanem, Ali
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机构:
Univ Texas Southwestern Med Ctr, Dept Neurol, Dallas, TX USAUniv Texas Southwestern Med Ctr, Med Sch, Dallas, TX USA
Ghanem, Ali
Sharma, Vibhash D.
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机构:
Univ Texas Southwestern Med Ctr, Dept Neurol, Dallas, TX USA
Univ Texas Southwestern Med Ctr, Peter ODonnell Jr Brain Inst, Dallas, TX USAUniv Texas Southwestern Med Ctr, Med Sch, Dallas, TX USA
Sharma, Vibhash D.
Louis, Elan D.
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机构:
Univ Texas Southwestern Med Ctr, Dept Neurol, Dallas, TX USA
Univ Texas Southwestern Med Ctr, Peter ODonnell Jr Brain Inst, Dallas, TX USA
Univ Texas Southwestern Med Ctr, Dept Neurol, 5323 Harry Hines Blvd, Dallas, TX 75390 USAUniv Texas Southwestern Med Ctr, Med Sch, Dallas, TX USA
机构:
NINDS, Clin Trials Unit, Off Clin Director, Intramural Res Program,NIH, Bldg 36,Rm 4D04, Bethesda, MD 20892 USANINDS, Clin Trials Unit, Off Clin Director, Intramural Res Program,NIH, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA
Haubenberger, Dietrich
Hallett, Mark
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机构:
NINDS, Human Motor Control Sect, Med Neurol Branch, Intramural Res Program,NIH, 9000 Rockville Pike,Bldg 10,Rm 7D37, Bethesda, MD 20892 USANINDS, Clin Trials Unit, Off Clin Director, Intramural Res Program,NIH, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA
Hallett, Mark
NEW ENGLAND JOURNAL OF MEDICINE,
2018,
378
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: 1802
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1810