miR-185 is an independent prognosis factor and suppresses tumor metastasis in gastric cancer

被引：15
作者：
Zhiqin Tan
Hao Jiang
Youhua Wu
Liming Xie
Wenxiang Dai
Hailin Tang
Sanyuan Tang
机构：
[1] University of South China,Center for Gastric Cancer Research of Human Province, The First Affiliated Hospital
[2] Sun Yat-Sen University Cancer Center,State Key Laboratory of Oncology in South China
[3] The 169th Hospital of PLA,Department of Gynaecology and Obstetrics
来源：
Molecular and Cellular Biochemistry | 2014年 / 386卷
关键词：
Gastric cancer; miR-185; Prognostic significance;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
miR-185 has been identified as an important factor in several cancers such as breast cancer, ovarial cancer, and prostate cancer. However, its effect and prognostic value in gastric cancer are still poorly known. In this study, we found that the expression levels of miR-185 were strongly downregulated in gastric cancer and associated with clinical stage and the presence of lymph node metastases. Moreover, miR-185 might independently predict OS and RFS in gastric cancer. We further found that upregulation of miR-185 inhibited the proliferation and metastasis of gastric cancer cells in vitro and in vivo. Taken together, our findings demonstrate that the miR-185 is important for gastric cancer initiation and progression and holds promise as a prognostic biomarker to predict survival and relapse in gastric cancer. It is also a potential therapeutic tool to improve clinical outcomes in the above disease.
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收藏
页码：223 / 231
页数：8
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