The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor

被引：0
作者：
Sarah E. Ewald
Bettina L. Lee
Laura Lau
Katherine E. Wickliffe
Guo-Ping Shi
Harold A. Chapman
Gregory M. Barton
机构：
[1] University of California,Division of Immunology & Pathogenesis, Department of Molecular and Cell Biology
[2] Berkeley,Department of Medicine
[3] 405 Life Sciences Addition,Department of Medicine
[4] Berkeley,undefined
[5] California 94720-3200,undefined
[6] USA,undefined
[7] Brigham and Women’s Hospital,undefined
[8] Harvard Medical School,undefined
[9] NRB-7,undefined
[10] 77 Avenue Louis Pasteur,undefined
[11] Boston,undefined
[12] Massachusetts 02115,undefined
[13] USA,undefined
[14] and The Cardiovascular Research Institute,undefined
[15] University of California,undefined
[16] San Francisco,undefined
[17] Box 0111,undefined
[18] San Francisco,undefined
[19] California 94143,undefined
[20] USA,undefined
来源：
Nature | 2008年 / 456卷
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摘要：
The role of the Toll-like receptors TLR9 and TLR7 in mediating autoimmune disease to self nucleic acid is now well appreciated, yet the mechanisms preventing rampant autoimmunity remain largely unknown. Here Ewald et al. define the route by which TLR9 and TLR7 exit the endoplasmic reticulum and travel to endolysosomes in mouse macrophages and dendritic cells. TLR9 activation is shown to require proteolytic cleavage in the endolysosome. This may be a strategy to restrict receptor activation to endolysosomal compartments and prevent TLRs from responding to self nucleic acids.
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页码：658 / 662
页数：4
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