Effects of Intranasally Administered Insulin and Gangliosides on Hypothalamic Signaling and Expression of Hepatic Gluconeogenesis Genes in Rats with Type 2 Diabetes Mellitus

被引:0
作者
I. O. Zakharova
L. V. Bayunova
K. V. Derkach
I. O. Ilyasov
I. Yu. Morina
A. O. Shpakov
N. F. Avrova
机构
[1] Sechenov Institute of Evolutionary Physiology and Biochemistry,
[2] Russian Academy of Sciences,undefined
来源
Journal of Evolutionary Biochemistry and Physiology | 2022年 / 58卷
关键词
insulin; gangliosides; intranasal administration; hypothalamus; signaling pathways; type 2 diabetes mellitus;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:1744 / 1765
页数:21
相关论文
共 566 条
[1]  
Petersen MC(2018)Mechanisms of Insulin Action and Insulin Resistance Physiol Rev 98 2133-2223
[2]  
Shulman GI(2014)Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future Lancet 383 1068-1083
[3]  
Kahn SE(2013)Cooperation between brain and islet in glucose homeostasis and diabetes Nature 503 59-66
[4]  
Cooper ME(2021)Brain control of blood glucose levels: implications for the pathogenesis of type 2 diabetes Diabetologia 64 5-14
[5]  
Del Prato S(2021)Central nervous system regulation of organismal energy and glucose homeostasis Nat Metab 3 737-750
[6]  
Schwartz MW(1997)Selective, physiological transport of insulin across the blood-brain barrier: novel demonstration by species-specific radioimmunoassays Peptides 18 1257-1262
[7]  
Seeley RJ(2004)The source of cerebral insulin Eur J Pharmacol 490 5-12
[8]  
Tschöp MH(2021)A historical perspective on the interactions of insulin at the blood-brain barrier J Neuroendocrinol 33 e12929-1679
[9]  
Woods SC(2021)Insulin signalling in tanycytes gates hypothalamic insulin uptake and regulation of AgRP neuron activity Nat Metab 3 1662-1570
[10]  
Morton GJ(1987)Localization and characterization of insulin receptors in rat brain and pituitary gland using in vitro autoradiography and computerized densitometry Endocrinology 121 1562-1224