Immunomodulating Properties of Humic Acids Extracted from Oligotrophic Sphagnum magellanicum Peat

被引：0
作者：
E. S. Trofimova
M. V. Zykova
M. G. Danilets
A. A. Ligacheva
E. Yu. Sherstoboev
A. V. Tsupko
D. A. Mikhalyov
M. V. Belousov
机构：
[1] E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine,
[2] Tomsk National Research Medical Center,undefined
[3] Russian Academy of Sciences,undefined
[4] Siberian State Medical University,undefined
[5] Ministry of Health of the Russian Federation,undefined
来源：
Bulletin of Experimental Biology and Medicine | 2021年 / 170卷
关键词：
humic acids; cytokines; humoral immune response; peritoneal macrophages; mononuclear cells;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Humic acids extracted with sodium pyrophosphate from Oligotrophic Sphagnum magellanicum peat reduce mitogen-stimulated production of anti-inflammatory cytokine IL-10 by mouse peritoneal macrophages and do not affect the secretion of IL-4 by lymphocytes. The studied humic acid sample stimulates the production of proinflammatory cytokines IL-12, TNFα, IL-1β, and IFNγ by immunocompetent mouse cells and human mononuclear cells. Course administration of humic acids to mice enhances the humoral immunity, increasing the number of antibody-forming cells in the spleen and the titer of antibodies in the blood serum after immunization with sheep red blood cells.
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页码：461 / 465
页数：4
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