Heterocyclization of N-(chlorosulfonyl)imidoyl chlorides with anilines, a new method of synthesis of 1,2,4-benzothiadiazine 1,1-dioxides

被引：0
作者：
Alexander A. Shalimov
Tetyana I. Chudakova
Yurii G. Vlasenko
Anatoly D. Sinitsa
Petro P. Onys’ko
机构：
[1] National Academy of Sciences of Ukraine,Institute of Organic Chemistry
来源：
Chemistry of Heterocyclic Compounds | 2016年 / 52卷
关键词：
anilines; 1,2,4-benzothiadiazine 1,1-dioxides; imidoyl chlorides; sulfonyl chlorides; heterocyclization;
D O I：
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摘要：
N-(Chlorosulfonyl)imidoyl chlorides react regioselectively with anilines, 2-aminomethylnaphthaline, or 1,2,3,4-tetrahydroquinoline leading to derivatives of 1,2,4-benzothiadiazine 1,1-dioxide. Heterocyclization occurs at the sterically less hindered C-6 atom in the case of 3-methoxy- and 3,4-dimethoxyaniline, while the reaction with 3-methylaniline leads to a mixture of cyclization products at the C-2 and C-6 atoms of aniline.
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页码：267 / 274
页数：7
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