Association study of a dopamine transporter polymorphism and attention deficit hyperactivity disorder in UK and Turkish samples

被引：0
作者：
S Curran
J Mill
E Tahir
L Kent
S Richards
A Gould
L Huckett
J Sharp
C Batten
S Fernando
F Ozbay
Y Yazgan
E Simonoff
M Thompson
E Taylor
P Asherson
机构：
[1] Social,Department of Psychiatry
[2] Genetic,Department of Child and Adolescent Psychiatry
[3] and Developmental Psychiatry Research Centre,undefined
[4] Institute of Psychiatry,undefined
[5] De Crespigny Park,undefined
[6] University of Birmingham,undefined
[7] Child and Family Health Centre,undefined
[8] Ashurst Hospital,undefined
[9] GKT Medical School,undefined
[10] TUBITAK,undefined
[11] Marmara Research Center,undefined
[12] Research Institute for Genetic Engineering and Biotechnology,undefined
[13] Marmara University School of Medicine,undefined
[14] Developmental Neuropsychiatry Research Unit,undefined
来源：
Molecular Psychiatry | 2001年 / 6卷
关键词：
dopamine transporter; DAT1; ADHD; genetic association;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Molecular genetic studies in attention deficit hyperactivity disorder (ADHD) have focussed on candidate genes within the dopamine system, which is thought to be the main site of action of stimulant drugs, the primary pharmacological treatment of the disorder.1 Of particular interest are findings with the dopamine transporter gene (DAT1), since stimulant drugs interact directly with the transporter protein.2,3 To date, there have been eight published association studies of ADHD with a 480 base-pair allele of a variable number tandem repeat (VNTR) polymorphism in the 3′-untranslated region of the gene, five4–8 that support an association and three9–11 against. We have analysed the same VNTR marker in a dataset of UK Caucasian children and an independent dataset of Turkish Caucasian children with DSM-IV ADHD, using the transmission disequilibrium test (TDT).12 Results from the UK (χ2 = 8.97, P = 0.001, OR = 1.95), but not the Turkish sample (χ2 = 0.93, P = 0.34) support association and linkage between genetic variation at the DAT1 locus and ADHD. When considered alongside evidence from other published reports, there is only modest evidence for the association, consistent with a very small main effect for the 480-bp allele (χ2 = 3.45, P = 0.06, OR = 1.15), however we find significant evidence of heterogeneity between the combined dataset (χ2 = 22.64, df = 8, P = 0.004).
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页码：425 / 428
页数：3
相关论文
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