Synthesis and Investigation of the Antibacterial Activity of New Tris-Thiourea Derivatives

被引：0
|
作者：
Saghi Shiroud Ghorbani
Naser Montazeri
Masoud Mohammadi Zeydi
Masood Ghane
机构：
[1] Islamic Azad University,Department of Chemistry, Faculty of Sciences
[2] Tonekabon Branch,Department of Microbiology
[3] Islamic Azad University,undefined
[4] Tonekabon Branch,undefined
来源：
Pharmaceutical Chemistry Journal | 2021年 / 55卷
关键词：
symmetrical ; -thioureas; benzoyl chlorides; potassium thiocyanate; melamine; antibacterial activity;
D O I：
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中图分类号：
学科分类号：
摘要：
An efficient procedure for the preparation of symmetrical tris-thiourea derivatives (5a – 5h) by means of one-pot condensation reaction between available benzoyl chlorides (1a –1h) with potassium thiocyanate (2) and melamine (4) under reflux conditions is presented. All the synthesized tris-thioureas were evaluated for their biological activities against a group of Gram-positive (Staphylococcus aureus and Bacillus cereus) and Gram-negative (Escherichia coli) bacteria. The synthesized compounds showed no activity against P. aeruginosa. All compounds exhibited excellent antibacterial activity against indicated bacterial strains. The new products were characterized using FT-IR, 1H and 13C NMR spectra, and elemental analysis.
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页码：60 / 64
页数：4
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