Enhanced Aqueous Dissolution of a Poorly Water Soluble Drug by Novel Particle Engineering Technology: Spray-Freezing into Liquid with Atmospheric Freeze-Drying

被引：0
|
作者：
True L. Rogers
Andrew C. Nelsen
Marazban Sarkari
Timothy J. Young
Keith P. Johnston
Robert O. Williams
机构：
[1] University of Texas at Austin,College of Pharmacy
[2] The Dow Chemical Company,undefined
[3] RxKINETIX,undefined
来源：
Pharmaceutical Research | 2003年 / 20卷
关键词：
spray-freezing into liquid; dissolution enhancement; danazol; atmospheric freeze-drying; micronization; particle engineering;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Purpose. The purpose of this work was to investigate spray-freezing into liquid (SFL) and atmospheric freeze-drying (ATMFD) as industrial processes for producing micronized SFL powders with enhanced aqueous dissolution. Micronized SFL powders dried by ATMFD were compared with vacuum freeze-dried SFL powders.
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页码：485 / 493
页数：8
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