Enhanced Aqueous Dissolution of a Poorly Water Soluble Drug by Novel Particle Engineering Technology: Spray-Freezing into Liquid with Atmospheric Freeze-Drying

被引：0
|
作者：
True L. Rogers
Andrew C. Nelsen
Marazban Sarkari
Timothy J. Young
Keith P. Johnston
Robert O. Williams
机构：
[1] University of Texas at Austin,College of Pharmacy
[2] The Dow Chemical Company,undefined
[3] RxKINETIX,undefined
来源：
Pharmaceutical Research | 2003年 / 20卷
关键词：
spray-freezing into liquid; dissolution enhancement; danazol; atmospheric freeze-drying; micronization; particle engineering;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Purpose. The purpose of this work was to investigate spray-freezing into liquid (SFL) and atmospheric freeze-drying (ATMFD) as industrial processes for producing micronized SFL powders with enhanced aqueous dissolution. Micronized SFL powders dried by ATMFD were compared with vacuum freeze-dried SFL powders.
引用
收藏
页码：485 / 493
页数：8
相关论文
共 22 条
  • [1] Enhanced aqueous dissolution of a poorly water soluble drug by novel particle engineering technology: Spray-freezing into liquid with atmospheric freeze-drying
    Rogers, TL
    Nelsen, AC
    Sarkari, M
    Young, TJ
    Johnston, KP
    Williams, RO
    PHARMACEUTICAL RESEARCH, 2003, 20 (03) : 485 - 493
  • [2] A novel particle engineering technology to enhance dissolution of poorly water soluble drugs: spray-freezing into liquid
    Rogers, TL
    Nelsen, AC
    Hu, JH
    Brown, JN
    Sarkari, M
    Young, TJ
    Johnston, KP
    Williams, RO
    EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2002, 54 (03) : 271 - 280
  • [3] A novel particle engineering technology: spray-freezing into liquid
    Rogers, TL
    Hu, JH
    Yu, ZS
    Johnston, KP
    Williams, RO
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2002, 242 (1-2) : 93 - 100
  • [4] Improvement of dissolution rates of poorly water soluble drugs using a new particle engineering technology - Spray Freezing into Liquid.
    Williams, RO
    Johnston, KP
    Hu, JH
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2003, 226 : U527 - U527
  • [5] Improvement of Dissolution Rates of Poorly Water Soluble APIs Using Novel Spray Freezing into Liquid Technology
    Jiahui Hu
    True L. Rogers
    Judith Brown
    Tim Young
    Keith P. Johnston
    Robert O. Williams III
    Pharmaceutical Research, 2002, 19 : 1278 - 1284
  • [6] Improvement of dissolution rates of poorly water soluble APIs using novel spray freezing into liquid technology
    Hu, JH
    Rogers, TL
    Brown, J
    Young, T
    Johnston, KP
    Williams, RO
    PHARMACEUTICAL RESEARCH, 2002, 19 (09) : 1278 - 1284
  • [7] Micronized powders of a poorly water soluble drug produced by a spray-freezing into liquid-emulsion process
    Rogers, TL
    Overhoff, KA
    Shah, P
    Santiago, P
    Yacaman, MJ
    Johnston, KP
    Williams, RO
    EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2003, 55 (02) : 161 - 172
  • [8] Improvement of dissolution rate of poorly water soluble drugs using a new particle engineering process: Spray freezing into liquid
    Overhoff, Kirk A.
    Johnston, Keith P.
    Williams, Robert O., III
    POLYMERIC DRUG DELIVERY II: POLYMERIC MATRICES AND DRUG PARTICLE ENGINEERING, 2006, 924 : 305 - 319
  • [9] Spray freezing into liquid (SFL) particle engineering technology to enhance dissolution of poorly water soluble drugs: organic solvent versus organic/aqueous co-solvent systems
    Hu, JH
    Johnston, KP
    Williams, RO
    EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2003, 20 (03) : 295 - 303
  • [10] Particle Characterization of Poorly Water-Soluble Drugs Using a Spray Freeze Drying Technique
    Kondo, Masahiro
    Niwa, Toshiyuki
    Okamoto, Hirokazu
    Danjo, Kazumi
    CHEMICAL & PHARMACEUTICAL BULLETIN, 2009, 57 (07) : 657 - 662
123