Effect of exposure to a country liquor (Toddy) during gestation on lipid metabolism in rats

The objective of this study was to determine theeffects of country liquor Toddy and its equivalentquantity of ethanol on lipid metabolism duringgestation in rats. Female rats weighing an average of125 g were exposed to Toddy (24.5 ml/body weight/day)and ethanol (0.52 ml/kg body weight/day) for 15 daysbefore conception and throughout gestation. On the19th day of gestation, altered liver function andhyperlipidemia was seen in both the treated groups.Altered liver function was evidenced by the increasedactivity of alcohol dehydrogenase, aldehydedehydrogenase, glutamic oxaloacetic transaminase oraspartate amino transferase (GOT), glutamic pyruvictransaminase or alanine amino transferase (GPT) andgamma glutamyl transpeptidase (GGT). Hyperlipidemiawas caused by increased biosynthesis and decreaseddegradation of lipids. The incorporation of 14Cacetate in lipids and activities of HMG CoA reductaseand lipogenic enzymes were elevated and activity ofLPL and bile acids contents were decreased. Toddytreated rats were more severely affected than thosereceiving an equivalent quantity of ethanol. Toddyseemed to potentiate the toxicity induced by alcoholindicating the role of the nonethanolic portion.Hepatic functions were also affected.