Rapid MALDI mass spectrometry imaging for surgical pathology

被引：0
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作者：
Sankha S. Basu
Michael S. Regan
Elizabeth C. Randall
Walid M. Abdelmoula
Amanda R. Clark
Begoña Gimenez-Cassina Lopez
Dale S. Cornett
Andreas Haase
Sandro Santagata
Nathalie Y. R. Agar
机构：
[1] Harvard Medical School,Department of Pathology, Brigham and Women’s Hospital
[2] Harvard Medical School,Department of Neurosurgery, Brigham and Women’s Hospital
[3] Harvard Medical School,Department of Radiology, Brigham and Women’s Hospital
[4] Bruker Daltonics,undefined
[5] Bruker Daltonik GmbH,undefined
[6] Ludwig Center at Harvard,undefined
[7] Harvard Medical School,undefined
来源：
npj Precision Oncology | / 3卷
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摘要：
Matrix assisted laser desorption ionization mass spectrometry imaging (MALDI MSI) is an emerging analytical technique, which generates spatially resolved proteomic and metabolomic images from tissue specimens. Conventional MALDI MSI processing and data acquisition can take over 30 min, limiting its clinical utility for intraoperative diagnostics. We present a rapid MALDI MSI method, completed under 5 min, including sample preparation and analysis, providing a workflow compatible with the clinical frozen section procedure.
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