Direct therapeutic targeting of immune checkpoint PD-1 in pancreatic cancer

[1] Rahib L(2014)Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States Cancer Res. 74 2913-2921

[2] Thomas RM(2008)The chemokine receptor CXCR4 is expressed in pancreatic intraepithelial neoplasia Gut 57 1555-1560

[3] Kim J(2012)Identification of anti-malarial compounds as novel antagonists to chemokine receptor CXCR4 in pancreatic cancer cells PLoS ONE 7 e31004-87

[4] Shen X(2010)Chemokine receptor CXCR4 enhances proliferation in pancreatic cancer cells through AKT and ERK dependent pathways Pancreas 39 81-1611

[5] Lee S(2015)CCR9-mediated signaling through beta-catenin and identification of a novel CCR9 antagonist Mol. Oncol. 9 1599-264

[6] Pardoll DM(2012)The blockade of immune checkpoints in cancer immunotherapy Nat. Rev. Cancer 12 252-203

[7] Raphael BJ(2017)Integrated genomic characterization of pancreatic ductal adenocarcinoma Cancer Cell. 32 185-1178

[8] Moffitt RA(2015)Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma Nat. Genet. 47 1168-607

[9] Barretina J(2012)The cancer cell line encyclopedia enables predictive modeling of anticancer drug sensitivity Nature 483 603-338

[10] Boj SF(2015)Organoid models of human and mouse ductal pancreatic cancer Cell 160 324-10567

[1] Rahib L(2014)Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States Cancer Res. 74 2913-2921

[2] Thomas RM(2008)The chemokine receptor CXCR4 is expressed in pancreatic intraepithelial neoplasia Gut 57 1555-1560

[3] Kim J(2012)Identification of anti-malarial compounds as novel antagonists to chemokine receptor CXCR4 in pancreatic cancer cells PLoS ONE 7 e31004-87

[4] Shen X(2010)Chemokine receptor CXCR4 enhances proliferation in pancreatic cancer cells through AKT and ERK dependent pathways Pancreas 39 81-1611

[5] Lee S(2015)CCR9-mediated signaling through beta-catenin and identification of a novel CCR9 antagonist Mol. Oncol. 9 1599-264

[6] Pardoll DM(2012)The blockade of immune checkpoints in cancer immunotherapy Nat. Rev. Cancer 12 252-203

[7] Raphael BJ(2017)Integrated genomic characterization of pancreatic ductal adenocarcinoma Cancer Cell. 32 185-1178

[8] Moffitt RA(2015)Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma Nat. Genet. 47 1168-607

[9] Barretina J(2012)The cancer cell line encyclopedia enables predictive modeling of anticancer drug sensitivity Nature 483 603-338

[10] Boj SF(2015)Organoid models of human and mouse ductal pancreatic cancer Cell 160 324-10567