Prevalence of hepatitis E virus viremia and antibodies among healthy blood donors in India

被引：16
作者：
Katiyar H. [1 ]
Goel A. [1 ]
Sonker A. [2 ]
Yadav V. [1 ]
Sapun S. [1 ]
Chaudhary R. [2 ]
Aggarwal R. [1 ]
机构：
[1] Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow
[2] Department of Transfusion Medicine, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow
来源：
Indian Journal of Gastroenterology | 2018年 / 37卷 / 4期
关键词：
Hepatitis E virus; Seroprevalence; Viral hepatitis; Viremia;
D O I：
10.1007/s12664-018-0880-7
中图分类号：
学科分类号：
摘要：
Background: Hepatitis E virus (HEV) is transmitted primarily through contaminated water and food. Recently, HEV viremia in blood donors and transfusion-related transmission of HEV have been reported, leading to calls to screen donated blood for this virus. However, these data are from regions where genotype 3 HEV is predominant. In India, where human infections are caused only by genotype 1 HEV, the frequency of subclinical HEV viremia is unknown. Methods: Minipools of sera prepared from three donor units each from our institution's blood bank in Lucknow, India, were tested for HEV RNA using a sensitive amplification-based assay. A randomly selected subset was also tested for IgG anti-HEV antibodies using a commercial (Wantai) immunoassay. Results: Sera from 1799 donors (median [range] age 30 [18–63] years; 1746 [97.0%] men) were collected (June–July 2016, 900; November–December 2016, 899). Of these, 17 (0.95%), 16 (0.90%), and 3 (0.17%) tested positive for HBsAg, anti-HCV, and anti-HIV antibodies, respectively. None of the donors tested positive for HEV RNA. Of 633 randomly selected donors (age 30 [18–63] years, 613 [96.8%] male) tested for IgG anti-HEV, 383 (60.5%) tested positive. Seropositivity rate increased with age, being 70/136 (52%), 177/299 (59%), 100/154 (65%), 30/34 (88%), and 6/10 (60%) in the 18–24, 25–34, 35–44, 45–54, and 55 years or older age groups, respectively. Conclusions: In healthy blood donors from northern India, HEV viremia is infrequent though anti-HEV antibody prevalence is high. This suggests that asymptomatic HEV viremia may be less frequent in areas with genotype 1 predominance than those with genotype 3 predominance. © 2018, Indian Society of Gastroenterology.
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页码：342 / 346
页数：4
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