Follicular helper T cells in immunity and systemic autoimmunity

被引：0
|
作者：
Joseph E. Craft
机构：
[1] Yale University School of Medicine,Departments of Internal Medicine (Rheumatology) and Immunobiology
来源：
Nature Reviews Rheumatology | 2012年 / 8卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Aberrant T-cell help has been implicated in the expansion of self-reactive B-cell clones and subsequent autoantibody production in many systemic autoimmune diseases, including systemic lupus erythematosus. In this Review, Joseph Craft discusses the T-helper-cell populations, particularly follicular helper T cells, which are key regulators of B-cell survival and maturation during normal immune responses and in autoimmunity.
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页码：337 / 347
页数：10
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