Molecular Mechanisms Underlying Differentiation of Thymocytes

被引：0
|
作者：
E. M. Kuklina
机构：
[1] Ural Branch of the Russian Academy of Sciences,Institute of Ecology and Genetics of Microorganisms
来源：
Russian Journal of Developmental Biology | 2003年 / 34卷 / 5期
关键词：
thymocytes; differentiation; apoptosis; clonal selection; linear commitment; TCR; pre-TCR; signal transduction;
D O I：
10.1023/A:1026017426279
中图分类号：
学科分类号：
摘要：
A review of the main molecular events occurring during differentiation of T-lymphocytes in the thymus: T-cell specialization of early intrathymic precursors, formation and expression of antigen receptor, formation of antigen recognizing cell repertoire, and αβ/γβ- and CD4/CD8-commitment. The mechanisms of glucocorticoid-induced apoptosis of thymocytes and its blockade during antigen-dependent activation are considered. A special attention is paid to the analysis of intracellular signals underlying the clonal selection of thymocytes.
引用
收藏
页码：285 / 299
页数：14
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