Molecular Mechanisms Underlying Differentiation of Thymocytes

被引：0
|
作者：
E. M. Kuklina
机构：
[1] Ural Branch of the Russian Academy of Sciences,Institute of Ecology and Genetics of Microorganisms
来源：
Russian Journal of Developmental Biology | 2003年 / 34卷 / 5期
关键词：
thymocytes; differentiation; apoptosis; clonal selection; linear commitment; TCR; pre-TCR; signal transduction;
D O I：
10.1023/A:1026017426279
中图分类号：
学科分类号：
摘要：
A review of the main molecular events occurring during differentiation of T-lymphocytes in the thymus: T-cell specialization of early intrathymic precursors, formation and expression of antigen receptor, formation of antigen recognizing cell repertoire, and αβ/γβ- and CD4/CD8-commitment. The mechanisms of glucocorticoid-induced apoptosis of thymocytes and its blockade during antigen-dependent activation are considered. A special attention is paid to the analysis of intracellular signals underlying the clonal selection of thymocytes.
引用
收藏
页码：285 / 299
页数：14
相关论文
共 50 条
  • [21] Molecular Mechanisms Underlying Pituitary Pathogenesis
    Sapochnik, Melanie
    Eduardo Nieto, Leandro
    Fuertes, Mariana
    Arzt, Eduardo
    BIOCHEMICAL GENETICS, 2016, 54 (02) : 107 - 119
  • [22] Molecular mechanisms underlying tumor dormancy
    Almog, Nava
    CANCER LETTERS, 2010, 294 (02) : 139 - 146
  • [23] Molecular mechanisms underlying gouty inflammation
    Rachel Murphy
    Nature Clinical Practice Rheumatology, 2006, 2 (4): : 177 - 178
  • [24] Molecular mechanisms underlying oxygen reception
    E. É. Kolesnikova
    Neurophysiology, 2004, 36 (4) : 293 - 309
  • [25] MOLECULAR MECHANISMS UNDERLYING SYNAPTIC TRANSMISSION
    BORMANN, J
    FRESENIUS ZEITSCHRIFT FUR ANALYTISCHE CHEMIE, 1984, 317 (06): : 624 - 625
  • [26] Molecular Mechanisms Underlying Hepatocellular Carcinoma
    Merle, Philippe
    Trepo, Christian
    VIRUSES-BASEL, 2009, 1 (03): : 852 - 872
  • [27] Molecular mechanisms underlying the activation of eNOS
    Ingrid Fleming
    Pflügers Archiv - European Journal of Physiology, 2010, 459 : 793 - 806
  • [28] Molecular Mechanisms Underlying Calcification in Coccolithophores
    Mackinder, Luke
    Wheeler, Glen
    Schroeder, Declan
    Riebesell, Ulf
    Brownlee, Colin
    GEOMICROBIOLOGY JOURNAL, 2010, 27 (6-7) : 585 - 595
  • [29] Molecular Mechanisms Underlying Oxygen Reception
    Kolesnikova, E. E.
    NEUROPHYSIOLOGY, 2004, 36 (04) : 293 - 309
  • [30] Molecular mechanisms underlying polyalanine diseases
    Messaed, C.
    Rouleau, G. A.
    NEUROBIOLOGY OF DISEASE, 2009, 34 (03) : 397 - 405
12345