Genetic variation at glucose and insulin trait loci and response to glucose–insulin–potassium (GIK) therapy: the IMMEDIATE trial

被引：0
作者：
K L Ellis
Y Zhou
J R Beshansky
E Ainehsazan
Y Yang
H P Selker
G S Huggins
L A Cupples
I Peter
机构：
[1] Icahn School of Medicine at Mount Sinai,Department of Genetics and Genomic Sciences
[2] Boston University School of Public Health,Department of Biostatistics
[3] Institute for Clinical Research and Health Policy Studies,undefined
[4] Tufts Medical Center,undefined
[5] Tufts University School of Medicine,undefined
[6] Molecular Cardiology Research Institute Center for Translational Genomics,undefined
[7] Tufts Medical Center,undefined
来源：
The Pharmacogenomics Journal | 2015年 / 15卷
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摘要：
The mechanistic effects of intravenous glucose, insulin and potassium (GIK) in cardiac ischemia are not well understood. We conducted a genetic sub-study of the Immediate Myocardial Metabolic Enhancement During Initial Assessment and Treatment in Emergency care (IMMEDIATE) Trial to explore effects of common and rare glucose and insulin-related genetic loci on initial to 6-h and 6- to 12-h change in plasma glucose and potassium. We identified 27 NOTCH2/ADAM30 and 8 C2CD4B variants conferring a 40–57% increase in glucose during the first 6 h of infusion (P<5.96 × 10−6). Significant associations were also found for ABCB11 and SLC30A8 single-nucleotide polymorphisms (SNPs) and glucose responses, and an SEC61A2 SNP with a potassium response to GIK. These studies identify genetic factors that may impact the metabolic response to GIK, which could influence treatment benefits in the setting of acute coronary syndromes (ACS).
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页码：55 / 62
页数：7
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