Is too much neurohormonal blockade harmful?

被引：3
作者：
Anand I.S. [1 ]
机构：
[1] VA Medical Center, Minneapolis, MN 55417, One Veterans Drive
来源：
Current Cardiology Reports | 2004年 / 6卷 / 3期
关键词：
Angiotensin Converting Enzyme; Etanercept; Chronic Heart Failure; Enalapril; Angiotensin Converting Enzyme Inhibitor;
D O I：
10.1007/s11886-004-0019-6
中图分类号：
学科分类号：
摘要：
A number of neurohormones and cytokines are activated in heart failure and their activity is related to the progression of heart failure. Inhibiting the deleterious effects of the activated sympathetic and the renin-angiotensin-aldosterone systems with β-blockers, angiotensin-converting enzyme inhibitors, and aldosterone blockers has been remarkably successful in improving the survival of patients with heart failure. However, inhibition of the other neurohormones and cytokines has not provided the expected incremental benefit, and in some cases has been deleterious, suggesting a ceiling effect of further neurohormonal blockade. This article reviews some of these studies and analyzes the possible causes of these observations. Copyright © 2004 by Current Science Inc.
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页码：169 / 175
页数：6
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