A Global Estimate of the Acceptability of Pre-exposure Prophylaxis for HIV Among Men Who have Sex with Men: A Systematic Review and Meta-analysis

被引:0
作者
Peng Peng
Shu Su
Christopher K. Fairley
Minjie Chu
Shengyang Jiang
Xun Zhuang
Lei Zhang
机构
[1] Nantong University,School of Public Health
[2] Monash University,School of Public Health and Preventive Medicine, Faculty of Medicine, Nursing and Health Sciences
[3] Melbourne Sexual Health Centre,Central Clinical School, Faculty of Medicine, Nursing and Health Science
[4] Alfred Health,undefined
[5] Monash University,undefined
来源
AIDS and Behavior | 2018年 / 22卷
关键词
Men who have sex with men; MSM; Pre-exposure prophylaxis; PrEP; Meta-analysis;
D O I
暂无
中图分类号
学科分类号
摘要
Pre-exposure prophylaxis (PrEP) is a new biomedical intervention for HIV prevention. This study systematically reviews the acceptability of PrEP among men who have sex with men (MSM) worldwide. We searched major English databases to identify English-language articles published between July 2007 and July 2016, which reported the acceptability of PrEP and associated population characteristics. Meta-analysis was conducted to estimate a pooled acceptability, and meta-regression and subgroup analysis were used to analyse heterogeneities. The estimated acceptance from included sixty-eight articles was 57.8% (95% confidence internal 52.4–63.1%). MSM who were younger (4/5 studies, range of adjusted odds ratio (aOR) = 1.39–3.47), better educated (aOR = 1.49–7.70), wealthier (aOR = 1.31–13.03) and previously aware of PrEP (aOR = 1.33–3.30) showed significantly higher acceptance. Male sex workers (84.0% [26.3–98.7%] were more likely to accept PrEP than general MSM. Self-perceived low efficacy, concern about side effects, adherence, affordability, and stigma were main barriers. This review identifies a moderate acceptability of PrEP in MSM. Efficacy, perception of HIV risk and experienced stigma determine its acceptance.
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页码:1063 / 1074
页数:11
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