Six new photolabile linkers for solid-phase synthesis. 1. Methods of preparation

被引：1

作者：

Åkerblom E.B. ^{[1
,2
]}

Nygren A.S. ^{[1
]}

Agback K.H. ^{[1
]}

机构：

[1] Medicinal Chemistry, Pharmacia and Upjohn AB

[2] Dept. of Organ. Pharmaceutical Chem., Uppsala Biomedical Center, Box 574

来源：

Molecular Diversity | 1997年 / 3卷 / 3期

关键词：

Combinatorial chemical library; Linkers; Photolysis; Solid-phase synthesis;

D O I：

10.1023/A:1009660431758

中图分类号：

学科分类号：

摘要：

In the synthesis of combinatorial chemical libraries on solid phase, there is a need to cleave the compounds from the solid support before the library can be tested for biological activity. It is advantageous to use linkers which will release the libraries by mild photolytic cleavage. We have developed six new linkers of the photosensitive α-methyl 2-nitrobenzyl type containing amino, hydroxy, bromo and methylamino groups, and also 4-nitrophenoxycarbonyl activated OH and NH2 groups.

引用

页码：137 / 148

页数：11

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