Following evolutionary paths to protein-protein interactions with high affinity and selectivity

被引：0
作者：
Kalia Bernath Levin
Orly Dym
Shira Albeck
Shlomo Magdassi
Anthony H Keeble
Colin Kleanthous
Dan S Tawfik
机构：
[1] Weizmann Institute of Science,Department of Biological Chemistry
[2] Casali Institute of Applied Chemistry,Department of Biology (Area 10)
[3] The Hebrew University of Jerusalem,undefined
[4] Givat Ram,undefined
[5] Jerusalem,undefined
[6] Israel.,undefined
[7] Israel Structural Proteomics Center,undefined
[8] Weizmann Institute of Science,undefined
[9] University of York,undefined
[10] Present address: Departments of Biochemistry and Infection,undefined
[11] Immunity and Inflammation,undefined
[12] University of Leicester,undefined
[13] Leicester,undefined
[14] UK.,undefined
来源：
Nature Structural & Molecular Biology | 2009年 / 16卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Colicins are secreted bacterial toxins. To avoid killing the producer organism, each colicin is coexpressed with a high-affinity inhibitor, or immunity protein (Im). The evolution of Im-Colicin interfaces and the evolvability traits of protein-protein interactions are now examined using in vitro evolution and structural analyses.
引用
收藏
页码：1049 / 1055
页数：6
相关论文
共 115 条
[1]  
Dean AM(2007)Mechanistic approaches to the study of evolution: the functional synthesis Nat. Rev. Genet. 8 675-688
[2]  
Thornton JW(2006)Evolution of hormone-receptor complexity by molecular exploitation Science 312 97-101
[3]  
Bridgham JT(2006)Direct demonstration of an adaptive constraint Science 314 458-461
[4]  
Carroll SM(2006)Darwinian evolution can follow only very few mutational paths to fitter proteins Science 312 111-114
[5]  
Thornton JW(2007)Crystal structure of an ancient protein: evolution by conformational epistasis Science 317 1544-1548
[6]  
Miller SP(2008)Elucidation of phenotypic adaptations: molecular analyses of dim-light vision proteins in vertebrates Proc. Natl. Acad. Sci. USA 105 13480-13485
[7]  
Lunzer M(2005)The 'evolvability' of promiscuous protein functions Nat. Genet. 37 73-76
[8]  
Dean AM(2001) evolution of β-glucuronidase into a β-galactosidase proceeds through non-specific intermediates J. Mol. Biol. 305 331-339
[9]  
Weinreich DM(2006)Enzyme promiscuity: evolutionary and mechanistic aspects Curr. Opin. Chem. Biol. 10 498-508
[10]  
Delaney NF(1993)Molecular mechanisms of colicin evolution Mol. Biol. Evol. 10 1380-1395
12345678910