Right ventricular failure complicating heart failure: Pathophysiology, significance, and management strategies

被引:21
作者
Mahmud M. [1 ]
Champion H.C. [1 ]
机构
[1] Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21205
关键词
Right Ventricular; Pulmonary Arterial Hypertension; Pulmonary Capillary Wedge Pressure; Bosentan; Levosimendan;
D O I
10.1007/BF02938351
中图分类号
学科分类号
摘要
Right heart failure most commonly results from the complication of left heart failure (systolic or nonsystolic dysfunction) or pulmonary hypertension. Over the past decade, greater attention has been paid to the role of right ventricular failure in the morbidity and mortality associated with cardiomyopathy and pulmonary hypertension. The right ventricle is distinct from the left ventricle not only in its spatial localization, but also in its response to increased afterload and signaling mechanisms. This article discusses the role of right ventricular failure in the setting of heart failure as well as the clinical diagnosis and management of right ventricular failure. Copyright © 2007 by Current Medicine Group LLC.
引用
收藏
页码:200 / 208
页数:8
相关论文
共 99 条
  • [1] Barst R.J., McGoon M., Torbicki A., Et al., Diagnosis and differential assessment of pulmonary arterial hypertension, J Am Coll Cardiol, 43, 12 SUPPL. S, (2004)
  • [2] Rich S., Pulmonary hypertension, Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, (2001)
  • [3] Voelkel N.F., Quaife R.A., Leinwand L.A., Et al., Right ventricular function and failure: Report of a National Heart, Lung, and Blood Institute working group on cellular and molecular mechanisms of right heart failure, Circulation, 114, pp. 1883-1891, (2006)
  • [4] Klotz S., Naka Y., Oz M.C., Burkhoff D., Biventricular assist device-induced right ventricular reverse structural and functional remodeling, J Heart Lung Transplant, 24, pp. 1195-1201, (2005)
  • [5] Klotz S., Barbone A., Reiken S., Et al., Left ventricular assist device support normalizes left and right ventricular beta-adrenergic pathway properties, J Am Coll Cardiol, 45, pp. 668-676, (2005)
  • [6] Mandarino W.A., Winowich S., Gasior T.A., Et al., Assessment of timing right ventricular assist device withdrawal using left ventricular assist device filling characteristics, Asaio J, 43, (1997)
  • [7] Mandarino W.A., Winowich S., Gorcsan 3rd J., Et al., Right ventricular performance and left ventricular assist device filling, Ann Thorac Surg, 63, pp. 1044-1049, (1997)
  • [8] Iskandrian A.S., Hakki A.H., Ren J.F., Et al., Correlation among right ventricular preload, afterload and ejection fraction in mitral valve disease: Radionuclide, echocardiographic and hemodynamic evaluation, J Am Coll Cardiol, 3, pp. 1403-1411, (1984)
  • [9] Szabo G., Soos P., Bahrle S., Et al., Adaptation of the right ventricle to an increased afterload in the chronically volume overloaded heart, Ann Thorac Surg, 82, pp. 989-995, (2006)
  • [10] Szabo G., Sebening C., Hagl C., Et al., Right ventricular function after brain death: Response to an increased afterload, Eur J Cardiothorac Surg, 13, pp. 449-458, (1998)