Effect of L-Arginine, Vitamin B6 and Folic Acid on Parameters of Endothelial Dysfunction and Microcirculation in the Placenta in Modelinhg of L-NAME-Induced NO Deficiency

被引:0
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作者
M. V. Korokin
M. V. Pokrovsky
O. O. Novikov
V. V. Gureev
T. A. Denisyuk
L. V. Korokina
O. S. Polyanskaya
V. A. Ragulina
T. G. Pokrovskaya
L. M. Danilenko
A. S. Belous
机构
[1] Kursk State Medical University,
[2] Ministry of Health Care and Social Development of the Russian Federation,undefined
关键词
endothelial dysfunction; gestosis; preeclampsia; vitamin B; folic acid;
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学科分类号
摘要
L-arginine (200 mg/kg), vitamin B6 (2 mg/kg), and folic acid (0.2 mg/kg) exert a protective effect on endothelial function in L-NAME-induced NO defi ciency in male and pregnant female Wistar rats. Combined administration of these agents effectively prevented the development of endothelial dysfunction and L-NAME-induced preeclampsia.
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页码:70 / 72
页数:2
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