In silico and network pharmacology analysis of fucosterol: a potent anticancer bioactive compound against HCC

被引:0
|
作者
Singh, Kajal [1 ]
Kumar, Pradeep [2 ]
Singh, Amit Kumar [3 ]
Singh, Nancy [1 ]
Singh, Sakshi [4 ]
Tiwari, Kavindra Nath [2 ]
Agrawal, Shreni [5 ]
Das, Richa [5 ]
Singh, Anuradha [1 ]
Ram, Bhuwal [6 ]
Tripathi, Amit Kumar [7 ]
Mishra, Sunil Kumar [3 ]
机构
[1] Galgotias Univ, Dept Biosci, Greater Noida, Uttar Pradesh, India
[2] Banaras Hindu Univ, Dept Bot, MMV, Varanasi 221005, Uttar Pradesh, India
[3] Banaras Hindu Univ, Indian Inst Technol, Dept Pharmaceut Engn & Technol, Varanasi 221005, UP, India
[4] Parul Univ, Parul Inst Appl Sci, Dept Biotechnol, Vadodara 391760, Gujarat, India
[5] Banasthali Vidhyapith, Dept Biosci & Biotechnol, Tonk, Rajsthan, India
[6] Banaras Hindu Univ, Dept Dravyaguna, IMS, Varanasi 221005, Uttar Pradesh, India
[7] Galgotias Univ, Sch Basic & Appl Sci, Greater Noida 203201, Uttar Pradesh, India
关键词
Fucosterol; Hub gene; HCC; ESR1; GeneCard; Gene ontology; HEPATOCELLULAR-CARCINOMA; ANDROGEN RECEPTOR; NUCLEAR RECEPTORS; CELLS; TUMOR; FUTURE; ALPHA; GENE;
D O I
10.1007/s12032-024-02374-w
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The Fucaceae family of marine brown algae includes Ascophyllum nodosum. Fucosterol (FSL) is a unique bioactive component that was identified through GC-MS analysis of the hydroalcoholic extract of A. nodosum. Fucosterol's mechanism of action towards hepatocellular cancer was clarified using network pharmacology and docking study techniques. The probable target gene of FSL has been predicted using the TargetNet and SwissTargetPred databases. GeneCards and the DisGNet database were used to check the targeted genes of FSL. By using the web programme Venny 2.1, the overlaps of FSL and HCC disease demonstrated that 18 genes (1.3%) were obtained as targeted genes Via the STRING database, a protein-protein interaction (PPI) network with 18 common target genes was constructed. With the aid of CytoNCA, hub genes were screened using the Cytoscape software, and the targets' hub genes were exported into the ShinyGo online tool for study of KEGG and gene ontology enrichment. Using the software AutoDock, a hub gene molecular docking study was performed. Ten genes, including AR, CYP19A1, ESR1, ESR2, TNF, PPARA, PPARG, HMGCR, SRC, and IGF1R, were obtained. The 10 targeted hubs docked with FSL successfully. The active components FSL of ASD, the FSL, are engaged in fatty liver disease, cancer pathways, and other signalling pathways, which could prove beneficial for the management of HCC.
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页数:14
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