Inventing a Sex-Specific Gene: A Conserved Role of DMRT1 in Teleost Fishes Plus a Recent Duplication in the Medaka Oryzias latipes Resulted in DMY

被引：0
作者：
Georges Lutfalla
Hugues Roest Crollius
Frédéric G. Brunet
Vincent Laudet
Marc Robinson-Rechavi
机构：
[1] UMR CNRS 5124,Défenses Antivirales et Antitumorales
[2] 1919,Genoscope
[3] Route de Mende,Laboratoire de Biologie Moléculaire et Cellulaire
[4] 34293 Montpellier Cedex 5,undefined
[5] UMR CNRS 8030,undefined
[6] 2,undefined
[7] rue Gaston Crémieux,undefined
[8] CP 5706,undefined
[9] 91057 Evry Cedex,undefined
[10] Ecole Normale Supérieure de Lyon,undefined
[11] UMR CNRS 5665,undefined
[12] 46 allée d’Italie,undefined
[13] 69364 Lyon Cedex 07,undefined
来源：
Journal of Molecular Evolution | 2003年 / 57卷
关键词：
Teleost fish; DMY gene; DMRT1 gene;
D O I：
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中图分类号：
学科分类号：
摘要：
DMY, the first sex-determining gene to be described in a nonmammal vertebrate was recently characterized in the medaka fish (Oryziaslatipes). It is homologous to DMRT1, a conserved gene of the sex determination cascade in vertebrates. We have checked the near complete genomes of two other percomorph fishes, Tetraodonnigroviridis and Takifugurubripes, for supplementary homologs of DMRT1 and DMY. We also compared the new gene, DMY, to its homolog DMRT1 from all available vertebrates. Finally, we found evidence for sex-specific expression and alternative splicing of the homolog from T. nigroviridis. Our results show that DMY is a recent duplicate of DMRT1 in the medaka. Its role in sex determination was not acquired through an acceleration of evolutionary rates, but by translocation to the Y chromosome and possibly changes at key positions.
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页码：S148 / S153
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