Synthesis and Immunomodulating Activity of New Amino Acid Derivatives of Glycyrrhizic Acid and Its Methyl Ester

被引：0
作者：
R. M. Kondratenko
L. A. Baltina
E. V. Vasil'eva
Kh. M. Nasyrov
R. M. Kireeva
N. Zh. Baschenko
S. M. Fridman
L. A. Baltina
G. A. Tolstikov
机构：
[1] Russian Academy of Sciences,Institute of Organic Chemistry, Ufa Scientific Center
来源：
Russian Journal of Bioorganic Chemistry | 2004年 / 30卷
关键词：
glycyrrhizic acid; amino acid derivatives; methyl ester; immunomodulating activity;
D O I：
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中图分类号：
学科分类号：
摘要：
New amino acid derivatives of glycyrrhizic acid and its methyl ester were selectively synthesized using active N-succinimide esters. The compounds with residues of glycine ethyl ester and alanine methyl and butyl esters increased the level of agglutinins and hemolysins in blood serum of mice two- to threefold in comparison with the control upon parenteral administration at a dose of 2 mg/kg for 14 days.
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页码：148 / 153
页数：5
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