Nifuroxazide Photodecomposition: Identification of the (Z)-isomer by 1H-NMR Study

被引：0

作者：

Natacha Boussac

Marie-Josèphe Galmier

Gérard Dauphin

Michel Madesclaire

Claire Lartigue

机构：

[1] UMR INSERM 484,

[2] Laboratoire de Chimie Analytique et de Spectrométrie de Masse,undefined

[3] UFR de Pharmacie,undefined

[4] Clermont-Ferrand Cédex,undefined

[5] France,undefined

[6] UMR 6504,undefined

[7] Laboratoire de Chimie Organique Biologique,undefined

[8] Université Blaise Pascal,undefined

[9] Aubière Cédex,undefined

[10] France,undefined

来源：

Microchimica Acta | 2003年 / 141卷

关键词：

Key words: Nifuroxazide stability; photoisomer; (E) and (Z) isomers; identification; 1H-NMR spectroscopy.;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The objective of this work was to identify the transformation product of nifuroxazide which appeared during stability studies of the drug in hard-capsules using high-performance liquid chromatography. The impurity appears on exposure to light, and test samples contained 21.5% of the impurity after two hours of exposure to light at room temperature. Mass spectrometry, infrared and nuclear magnetic resonance spectroscopy indicated the occurrence of a geometric isomer of nifuroxazide. In general, 1H-1H NOE difference experiments after irradiation were in agreement with a photochemical Z/E isomerisation of nifuroxazide following exposure to ambient light.

引用

页码：179 / 181

页数：2