Dosage compensation in drosophila: Sequence-specific initiation and sequence-independent spreading of MSL complex to the active genes on the male X chromosome

被引：0
作者：
Andrey A. Gorchakov
Artyom A. Alekseyenko
Peter V. Kharchenko
Peter J. Park
Mitzi I. Kuroda
机构：
[1] Brigham & Women’s Hospital,Division of Genetics, Dept. of Medicine
[2] Harvard Medical School,Department of Genetics
[3] Institute of Chemical Biology and Fundamental Medicine SB RAS,Department of Molecular and Cellular Biology
[4] Harvard Medical School,Center for Biomedical Informatics
[5] Children’s Hospital,Informatics Program
来源：
Russian Journal of Genetics | 2010年 / 46卷
关键词：
Dosage Compensation; Dosage Compensation Complex; Male Larva; Exquisite Specificity; ChIP Chip;
D O I：
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中图分类号：
学科分类号：
摘要：
For the dosage compensation to occur, genes on the single male X chromosomes in Drosophila must be selectively bound and acetylated by the ribonucleoprotein complex called MSL complex. It remained unknown how such exquisite specificity is achieved, and whether specific DNA sequences were involved. In the present work we demonstrate that it is transcription of the gene on the X chromosome that is important for MSL targeting, irrespective of gene origin and DNA sequence.
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页码：1263 / 1266
页数：3
相关论文
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