The biological significance of angiotensin-converting enzyme inhibition to combat kidney fibrosis

被引：0
作者：
Takako Nagai
Kyoko Nitta
Megumi Kanasaki
Daisuke Koya
Keizo Kanasaki
机构：
[1] Kanazawa Medical University,Department of Diabetology and Endocrinology
来源：
Clinical and Experimental Nephrology | 2015年 / 19卷
关键词：
RAS; SDKP; FGF; microRNA; Tissue repair;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Both angiotensin-converting enzyme inhibitor (ACE-I) and angiotensin II receptor blocker have been recognized as renin–angiotensin system (RAS) inhibitors. These two RAS inhibitors are rarely recognized as drugs with distinct pharmacological effects in the clinic or most clinical trials. Some preclinical basic research and clinical trials indicate that ACE-I might display superior organ-protective effects, especially anti-fibrotic effects. Such anti-fibrotic effects of ACE-I could be associated with an endogenous anti-fibrotic peptide, N-acetyl-seryl-aspartyl-lysyl-proline (AcSDKP). In this review, we focused on the anti-fibrotic effects of RAS inhibition and the endogenous anti-fibrotic peptide AcSDKP.
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页码：65 / 74
页数：9
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