Hair analysis following chronic smoked-drugs-of-abuse exposure in adults and their toddler: A case report

被引:1
作者
Papaseit E. [1 ,2 ,3 ]
Joya X. [1 ,2 ,3 ]
Velasco M. [3 ]
Civit E. [1 ]
Mota P. [3 ]
Bertran M. [3 ]
Vall O. [1 ,2 ,3 ]
Garcia-Algar O. [1 ,2 ,3 ]
机构
[1] Programa de Recerca en Neurociències, IMIM, Hospital Del Mar, Barcelona, arc de Salut Mar
[2] Grup de Recerca i Entorn (GRIE), Institut de Recerca, Hospital Del Mar, Barcelona, Parc de Salut Mar
[3] Universitat Autónoma de Barcelona, Barcelona
关键词
Cocaine; Hair Sample; Cocaine Exposure; Hair Analysis; Chronic Cocaine;
D O I
10.1186/1752-1947-5-570
中图分类号
学科分类号
摘要
Introduction. Over the past two decades, the study of chronic cocaine and crack cocaine exposure in the pediatric population has been focused on the potential adverse effects, especially in the prenatal period and early childhood. Non-invasive biological matrices have become an essential tool for the assessment of a long-term history of drug of abuse exposure. Case report. We analyze the significance of different biomarker values in hair after chronic crack exposure in a two-year-old Caucasian girl and her parents, who are self-reported crack smokers. The level of benzoylecgonine, the principal metabolite of cocaine, was determined in segmented hair samples (0 cm to 3 cm from the scalp, and > 3 cm from the scalp) following washing to exclude external contamination. Benzoylecgonine was detectable in high concentrations in the child's hair, at 1.9 ng/mg and 7.04 ng/mg, respectively. Benzoylecgonine was also present in the maternal and paternal hair samples at 7.88 ng/mg and 6.39 ng/mg, and 13.06 ng/mg and 12.97 ng/mg, respectively. Conclusion: Based on the data from this case and from previously published poisoning cases, as well as on the experience of our research group, we conclude that, using similar matrices for the study of chronic drug exposure, children present with a higher cocaine concentration in hair and they experience more serious deleterious acute effects, probably due to a different and slower cocaine metabolism. Consequently, children must be not exposed to secondhand crack smoke under any circumstance. © 2011 Papaseit et al; licensee BioMed Central Ltd.
引用
收藏
相关论文
共 29 条
[1]  
Smart R.G., Crack cocaine use: A review of prevalence and adverse effects, Am J Drug Alcohol Abuse, 17, pp. 13-26, (1991)
[2]  
Haim D.Y., Lippmann M.L., Goldberg S.K., Walkenstein M.D., The pulmonary complications of crack cocaine. A comprehensive review, Chest, 107, pp. 233-240, (1995)
[3]  
Hirche T.O., Lambrecht F., Wagner T.O.F., Crack-syndrom: Pulmonale komplikationen nach kokaininhalation. Kasuistik und darstellung des krankheitsbildes, Pneumologie, 56, 11, pp. 684-688, (2002)
[4]  
Perper J.A., Van Thiel D.H., Respiratory complications of cocaine abuse, Recent Dev Alcohol, 10, pp. 363-377, (1992)
[5]  
Barroso M., Gallardo E., Queiroz J.A., Bioanalytical methods for the determination of cocaine and metabolites in human biological samples, Bioanalysis, 1, pp. 977-1000, (2009)
[6]  
Kintz P., Villain M., Cirimele V., Hair analysis for drug detection, Therapeutic Drug Monitoring, 28, 3, pp. 442-446, (2006)
[7]  
Pragst F., Balikova M.A., State of the art in hair analysis for detection of drug and alcohol abuse, Clinica Chimica Acta, 370, 1-2, pp. 17-49, (2006)
[8]  
Garcia-Algar O., Papaseit E., Velasco M., Lapez N., Martinez L., Luaces C., Vall O., Drugs of abuse acute intoxication in paediatric emergencies, An Pediatr (Barc), 74, pp. 413-416, (2011)
[9]  
Tsanaclis L., Wicks J.F.C., Differentiation between drug use and environmental contamination when testing for drugs in hair, Forensic Science International, 176, 1, pp. 19-22, (2008)
[10]  
Koren G., Klein J., Forman R., Graham K., Hair analysis of cocaine: Differentiation between systemic exposure and external contamination, J Clin Pharmacol, 32, pp. 671-675, (1992)