Practical one-pot synthesis of semicarbazone derivatives via semicarbazide, and evaluation of their antibacterial activity

被引：0
|
作者：
Nosrat O. Mahmoodi
Mojtaba Namroudi
Fateme Ghanbari Pirbasti
Hossein Roohi
Iraj Nikokar
机构：
[1] University of Guilan,Department of Organic Chemistry, Faculty of Sciences
[2] Guilan University of Medical Sciences,Laboratory of Microbiology and Immunology of Infectious Diseases, Paramedicine Faculty
来源：
Research on Chemical Intermediates | 2016年 / 42卷
关键词：
Semicarbazone; Hydrazine hydrate; Phenyl isocyanate; One-pot reaction; Antibacterial;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
New series of 2-(aryl or alkyl)-N-phenylhydrazine-1-carboxamides 1a–j were synthesized through one-pot reactions of aldehyde or ketones, hydrazine hydrate, and phenylisocyanate in MeOH. The structure of products was confirmed by Fourier transform infrared (FT-IR), proton nuclear magnetic resonance (1H NMR), and 13C NMR spectra. Minimum inhibitory concentration (MIC) of antibacterial activity of 1a–j was screened against five bacterial strains. Compound 1f showed antibacterial activity against Pseudomonas aeruginosa and Staphylococcus aureus.
引用
收藏
页码：3625 / 3636
页数：11
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