Nanoparticulate X-ray CT contrast agents

被引：0
作者：
Wenya He
Kelong Ai
Lehui Lu
机构：
[1] Chinese Academy of Sciences,State Key Laboratory of Electroanalytical Chemistry; Changchun Institute of Applied Chemistry
来源：
Science China Chemistry | 2015年 / 58卷
关键词：
X-ray computed tomography (CT); contrast agents; nanoparticles; iodine;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
X-ray computed tomography (CT) has been widely used as a powerful diagnostic tool in clinics because it can provide high-resolution 3D tomography of the anatomic structure based on the distinctive X-ray absorptions between different tissues. Currently, CT contrast agents are mainly small iodinated molecules, which suffer from drawbacks such as short bloodretention time, nonspecific in vivo biodistribution, and renal toxicity. Utilization of nanoparticles as potential CT contrast agents to overcome the aforementioned issues has advanced rapidly. In this mini review, we introduce current research efforts in the development of nanoparticulate CT contrast agents and discuss the challenges for additional breakthroughs in this field.
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页码：753 / 760
页数：7
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